Evidence map›Paper›PMID 34045488›Full record

ReviewNature reviews. Disease primers2021

Contact dermatitis.

Pamela L Scheinman, Marc Vocanson, Jacob P Thyssen, Jeanne Duus Johansen, Rosemary L Nixon, Kate Dear, Nina C Botto, Johanna Morot, Ari M Goldminz

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07286487 (Effects of Glycyrrhetinic Acid on Human Skin in an Acute Irritant Contact Dermatitis Model), which is not on this map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07286487 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Glycyrrhetinic Acid on Human Skin in an Acute Irritant Contact Dermatitis Model

TypeinterventionalSponsorUniversity of Split, School of MedicineRan2026 to 2027Enrolled30ConditionsIrritant Contact DermatitisArmsSLS induced irritation, No Treatment, Placebo, Lower Dose Glycyrrhetinic Acid, Higher Dose Glycyrrhetinic Acid
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pigmented contact cheilitis: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2024
    Pooled it
  3. Article
  4. Article
  5. Article
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  14. Review
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  19. Review
  20. NFATc1 Abrogation in B Cells Ameliorates Contact Hypersensitivity Responses.International journal of molecular sciences · 2025
    Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pamela L ScheinmanDepartment of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
Marc VocansonCIRI - Centre International de Recherche en Infectiologie, INSERM, U1111; Univ Lyon; Université Claude Bernard Lyon 1; Ecole Normale Supérieure de Lyon; CNRS, UMR, 5308, Lyon, France.
Jacob P ThyssenNational Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jeanne Duus JohansenNational Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Rosemary L NixonSkin Health Institute - Occupational Dermatology Research and Education Centre, Carlton, VIC, Australia.
Kate DearSkin Health Institute - Occupational Dermatology Research and Education Centre, Carlton, VIC, Australia.
Nina C BottoDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5408-7346
Johanna MorotCIRI - Centre International de Recherche en Infectiologie, INSERM, U1111; Univ Lyon; Université Claude Bernard Lyon 1; Ecole Normale Supérieure de Lyon; CNRS, UMR, 5308, Lyon, France.
Ari M GoldminzDepartment of Dermatology, Brigham and Women's Hospital, Boston, MA, USA. agoldminz@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-7910-1901

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contact dermatitis (CD) is among the most common inflammatory dermatological conditions and includes allergic CD, photoallergic CD, irritant CD, photoirritant CD (also called phototoxic CD) and protein CD. Occupational CD can be of any type and is the most prevalent occupational skin disease. Each CD type is characterized by different immunological mechanisms and/or requisite exposures. Clinical manifestations of CD vary widely and multiple subtypes may occur simultaneously. The diagnosis relies on clinical presentation, thorough exposure assessment and evaluation with techniques such as patch testing and skin-prick testing. Management is based on patient education, avoidance strategies of specific substances, and topical treatments; in severe or recalcitrant cases, which can negatively affect the quality of life of patients, systemic medications may be needed.

Indexed as

Dermatitis, Allergic ContactDermatitis, IrritantAllergensHumansPatch TestsQuality of LifeAllergens

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.