ArticleNature communications2021
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 116 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
116 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Age-related differences in hippocampal subfield volumes across the human lifespan: A meta-analysis.Hippocampus · 2023Pooled it
- In vivo quantitative imaging of hippocampal inflammation in autoimmune neuroinflammatory conditions: a systematic review.Clinical and experimental immunology · 2022Pooled it
- Arterial stiffness moderates the link between NfL and cognition: The IGNITE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Acute hypoxia impairs posterior cerebral bioenergetics and memory in man.Experimental physiology · 2023Trial
- Hypoxia Triggers BNIP3/BNIP3L-Associated Mitophagy in HT22 Immortalized Hippocampal Neurons: A Temporal Descriptive Study.Biology · 2026Article
- Article
- Computer models predict differential dendritic vulnerability with ischemia and spreading depression.PLoS computational biology · 2026Article
- Brain-Wide Activations Related to Forepaw Force Control Identified by Behaving Mouse FMRI.eNeuro · 2026Article
- A review of animal models of vascular dementia.Molecular biology reports · 2026Review
- Evaluation of the diffusion time dependence of the IVIM effect based on realistic capillary flow simulations in mouse brain.Magma (New York, N.Y.) · 2026Article
- Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.GeroScience · 2026Article
- Longitudinal multiphoton imaging of cerebral amyloid angiopathy in response to anti-ApoE4 immunotherapy in mice.Molecular neurodegeneration · 2026Article
- Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.Epilepsia · 2026Article
- Multiple sevoflurane exposures in early development lead to long-term vascular abnormalities in the hippocampus.Cell biology and toxicology · 2026Article
- BOLD signal changes can oppose oxygen metabolism across the human cortex.Nature neuroscience · 2026Article
- Hypoxia or tobacco-smoke exposure induce region-specific microvascular remodeling in the brain.Scientific reports · 2026Article
- Neurovascular decoupling: An early indicator of cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Direct Evidence for the Feedforward Neurovascular Coupling Mechanism in Humans During Task Onset: An EEG-fNIRS-TCD Multimodal Imaging Study.Sensors (Basel, Switzerland) · 2026Article
- Low interstitial fluid in patients with spontaneous intracranial hypotension.Fluids and barriers of the CNS · 2026Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The hippocampus is essential for spatial and episodic memory but is damaged early in Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its oxygen supply is therefore key for designing interventions to preserve its function. However, studies of neurovascular function in the hippocampus in vivo have been limited by its relative inaccessibility. Here we compared hippocampal and visual cortical neurovascular function in awake mice, using two photon imaging of individual neurons and vessels and measures of regional blood flow and haemoglobin oxygenation. We show that blood flow, blood oxygenation and neurovascular coupling were decreased in the hippocampus compared to neocortex, because of differences in both the vascular network and pericyte and endothelial cell function. Modelling oxygen diffusion indicates that these features of the hippocampal vasculature may restrict oxygen availability and could explain its sensitivity to damage during neurological conditions, including Alzheimer's disease, where the brain's energy supply is decreased.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.