ArticleEpidemiology and psychiatric sciences2021
Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study.
Article in Epidemiology and psychiatric sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Allostatic load index across the psychosis spectrum: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis.Psychological medicine · 2023Pooled it
- Candidate Targets for Resilience Training to Reduce Transdiagnostic Risk for Mental Illness.Schizophrenia bulletin · 2026Article
- Temporal Relationship Between Momentary Negative Affect Intensity and Momentary Attenuated Delusions in Individuals at Clinical High-risk for Psychosis.Schizophrenia bulletin · 2026Article
- The associations of stress, pleasure and emotion to voice-hearing: An ecological momentary assessment study.Psychology and psychotherapy · 2025Article
- Childhood trauma and recent stressors in predicting subclinical psychotic symptoms among Chinese university students in southwest China: a machine learning analysis within a gender-specific framework.BMJ mental health · 2025Article
- The relationship between stress and clinical high-risk symptoms of psychosis in daily life: impact of contemporaneous paths on cross-lagged effects.Psychological medicine · 2025Article
- The Role of Childhood Trauma in Affective Stress Recovery in Early Psychosis: An Experience Sampling Study.Schizophrenia bulletin · 2024Article
- Associations between disturbed sleep and attenuated psychotic experiences in people at clinical high risk for psychosis.Psychological medicine · 2024Article
- The Translational Future of Stress Neurobiology and Psychosis Vulnerability: A Review of the Evidence.Current neuropharmacology · 2024Review
- Environmental context predicts state fluctuations in negative symptoms in youth at clinical high risk for psychosis.Psychological medicine · 2023Article
- Temporal Interactions Between Social Motivation and Behavior In Daily Life Among Individuals at Clinical High-Risk for Psychosis.Schizophrenia bulletin · 2023Article
- The Critical Roles of Early Development, Stress, and Environment in the Course of Psychosis.Annual review of developmental psychology · 2022Article
- Positive Affective Recovery in Daily Life as a Momentary Mechanism Across Subclinical and Clinical Stages of Mental Disorder: Experience Sampling Study.JMIR mental health · 2022Article
- Recovery After Stress-Autonomic and Subjective Arousal in Individuals With Psychosis Compared to Healthy Controls.Schizophrenia bulletin · 2022Article
- Facing the pandemic and lockdown: an insight on mental health from a longitudinal study using diaries.Schizophrenia (Heidelberg, Germany) · 2022Article
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Authors and funding
16 authors at 7 institutions in 6 countries.
Funding
Abstract
aimsChildhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes in individuals at ultra-high-risk (UHR) for psychosis.
methodsExperience sampling methodology was used to measure momentary stress, affect and psychotic experiences in the daily life of N = 79 UHR individuals in the EU-GEI High Risk Study. The Childhood Trauma Questionnaire was used to assess self-reported childhood trauma. Clinical outcomes were assessed at baseline, 1- and 2-year follow-up.
resultsThe association of stress with positive (β = -0.14, p = 0.010) and negative affect (β = 0.11, p = 0.020) was modified by transition status such that stress reactivity was greater in individuals who transitioned to psychosis. Moreover, the association of stress with negative affect (β = 0.06, p = 0.019) and psychotic experiences (β = 0.05, p = 0.037) was greater in individuals exposed to high v. low levels of childhood trauma. We also found evidence that decreased positive affect in response to stress was associated with reduced functioning at 1-year follow-up (B = 6.29, p = 0.034). In addition, there was evidence that the association of childhood trauma with poor functional outcomes was mediated by stress reactivity (e.g. indirect effect: B = -2.13, p = 0.026), but no evidence that stress reactivity mediated the association between childhood trauma and transition (e.g. indirect effect: B = 0.14, p = 0.506).
conclusionsEmotional and psychotic stress reactivity may be potential mechanisms linking childhood trauma with clinical outcomes in UHR individuals.
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