ArticleBiology of sex differences2021
A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta.
Article in Biology of sex differences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis.Epigenetics · 2023Pooled it
- Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.Mutation research. Reviews in mutation researchPooled it
- Prenatal social support in low-risk pregnancy shapes placental epigenome.BMC medicine · 2023Trial
- Characterizing placental dysfunction with DNA methylation profiling and placental histopathology.Placenta · 2026Article
- Sex-influenced DNA methylation differs by placental cell type.Biology of sex differences · 2026Article
- Dietary caffeine to assess CYP1A2 activity, tailor clozapine doses, and predict treatment response: genetic, epigenetic and clinical analyses.Molecular psychiatry · 2026Article
- Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses.Molecular psychiatry · 2025Article
- Sex-differentiated placental methylation and gene expression regulation has implications for neonatal traits and adult diseases.Nature communications · 2025Article
- Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta.Biology of sex differences · 2025Article
- Article
- Mode of delivery may seriously affect omics studies using umbilical cord blood and amniotic fluid.Archives of gynecology and obstetrics · 2024Article
- Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.Biology of sex differences · 2024Article
- Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis.Cellular and molecular life sciences : CMLS · 2024Article
- Article
- Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024Review
- Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas.Biology of sex differences · 2024Article
- Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study.Epigenetics · 2023Article
- DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study.Clinical epigenetics · 2023Article
- The application of epiphenotyping approaches to DNA methylation array studies of the human placenta.Epigenetics & chromatin · 2023Article
- Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns.BMC biology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHuman placental DNA methylation (DNAme) data is a valuable resource for studying sex differences during gestation, as DNAme profiles after delivery reflect the cumulative effects of gene expression patterns and exposures across gestation. Here, we present an analysis of sex differences in autosomal DNAme in the uncomplicated term placenta (n = 343) using the Illumina 450K array.
resultsAt a false discovery rate < 0.05 and a mean sex difference in DNAme beta value of > 0.10, we identified 162 autosomal CpG sites that were differentially methylated by sex and replicated in an independent cohort of samples (n = 293). Several of these differentially methylated CpG sites were part of larger correlated regions of sex differential DNAme. Although global DNAme levels did not differ by sex, the majority of significantly differentially methylated CpGs were more highly methylated in male placentae, the opposite of what is seen in differential methylation analyses of somatic tissues. Patterns of autosomal DNAme at these 162 CpGs were significantly associated with maternal age (in males) and newborn birthweight standard deviation (in females).
conclusionsOur results provide a comprehensive analysis of sex differences in autosomal DNAme in the term human placenta. We report a list of high-confidence autosomal sex-associated differentially methylated CpGs and identify several key features of these loci that suggest their relevance to sex differences observed in normative and complicated pregnancies.
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