Evidence map›Paper›PMID 34044868›Full record

Observational studyWorld journal of emergency surgery : WJES2021

Antithrombotic drugs have a minimal effect on intraoperative blood loss during emergency surgery for generalized peritonitis: a nationwide retrospective cohort study in Japan.

Tadashi Matsuoka, Nao Ichihara, Hiroharu Shinozaki, Kenji Kobayashi, Alan Kawarai Lefor, Toshimoto Kimura, Yuko Kitagawa, Yoshihiro Kakeji, Hiroaki Miyata, Junichi Sasaki

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of emergency surgery : WJES, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Tadashi MatsuokaDepartment of Emergency and Critical Care Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinkjuku, Tokyo, 164-8582, Japan. tadashi_matsuoka1984@yahoo.co.jp.ORCID 0000-0002-3837-8960
Nao IchiharaDepartment of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroharu ShinozakiDepartment of Surgery, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Kenji KobayashiDepartment of Surgery, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Alan Kawarai LeforDepartment of Surgery, Jichi Medical University, Tochigi, Japan.
Toshimoto KimuraDepartment of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.
Yuko KitagawaThe Japanese Society of Gastroenterological Surgery, Tokyo, Japan.
Yoshihiro KakejiDatabase Committee, The Japanese Society of Gastroenterological Surgery, Tokyo, Japan.
Hiroaki MiyataDepartment of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Junichi SasakiDepartment of Emergency and Critical Care Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinkjuku, Tokyo, 164-8582, Japan.
Keio University · JPSaiseikai Utsunomiya hospital · JPThe Japanese Society of Gastroenterological Surgery · JPIwate Medical University · JPJichi Medical University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effect of antithrombotic drugs on intraoperative operative blood loss volume in patients undergoing emergency surgery for generalized peritonitis is not well defined. The purpose of this study was to investigate the effect of antithrombotic drugs on intraoperative blood loss in patients with generalized peritonitis using a nationwide surgical registry in Japan.

methodThis retrospective cohort study used a nationwide surgical registry data from 2011 to 2017 in Japan. Propensity score matching for the use of antithrombotic drugs was used for the adjustment of age, gender, comorbidities, frailty, preoperative state, types of surgery, surgical approach, laboratory data, and others. The main outcome was intraoperative blood loss: comparison of intraoperative blood loss, ratio of intraoperative blood loss after adjusted for confounding factors, and variable importance of all covariates.

resultsA total of 70,105 of the eligible 75,666 patients were included in this study, and 2947 patients were taking antithrombotic drugs. Propensity score matching yielded 2864 well-balanced pairs. The blood loss volume was slightly higher in the antithrombotic drug group (100 [10-349] vs 70 [10-299] ml). After adjustment for confounding factors, the use of antithrombotic drugs was related to a 1.30-fold increase in intraoperative blood loss compared to non-use of antithrombotic drugs (95% CI, 1.16-1.45). The variable importance revealed that the effect of the use of antithrombotic drugs was minimal compared with surgical approach or type of surgery.

conclusionThis study shows that while taking antithrombotic drugs is associated with a slight increase in intraoperative blood loss in patients undergoing emergency surgery for generalized peritonitis, the effect is likely of minimal clinical significance.

Indexed as

AgedAged, 80 and overBlood Loss, SurgicalEmergenciesFemaleFibrinolytic AgentsHumansJapanMaleMiddle AgedPeritonitisPropensity ScoreRegistriesRetrospective StudiesFibrinolytic AgentsAntithrombotic drugEmergency gastrointestinal surgeryGeneralized peritonitisIntraoperative blood loss

Identifiers

PMID34044868
PMCPMC8162009
OpenAlexW3159139941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.