ArticleParasites & vectors2021
Identification of tick-borne pathogens by metagenomic next-generation sequencing in Dermacentor nuttalli and Ixodes persulcatus in Inner Mongolia, China.
Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 55 citations in OpenAlex.
- Molecular Detection ofPathogens (Basel, Switzerland) · 2026Article
- High throughput sequencing in the diagnosis and surveillance of tick-borne diseases: A narrative review.One health (Amsterdam, Netherlands) · 2026Review
- Ecological niche and rickettsial risk mapping ofFrontiers in cellular and infection microbiology · 2026Article
- Research progress on emerging and important Tick-Borne pathogens.Frontiers in microbiology · 2026Review
- Molecular characterization of livestock-associated ticks and tick-borne bacteria in Xinjiang, northwestern China.Parasites & vectors · 2025Article
- The differences in microbial communities and Tick-Borne pathogens between Dermacentor marginatus and Hyalomma asiaticum collected from the Northwestern Xinjiang Uygur Autonomous Region, China.BMC infectious diseases · 2025Article
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- Deciphering the microbial communities in ticks of Inner Mongolia: ecological determinants and pathogen profiles.Parasites & vectors · 2024Article
- 16S rRNA metabarcoding for the identification of tick-borne bacteria in ticks in the Republic of Korea.Scientific reports · 2024Article
- Borrelia theileri infections in Rhipicephalus annulatus ticks from the north of Iran.Experimental & applied acarology · 2024Article
- Evidence of zoonotic rickettsiae in ixodid ticks of domestic animals in some communal farms in the Eastern Cape Province, South Africa.Journal of advanced veterinary and animal research · 2024Article
- Surveillance of tick-borne bacteria infection in ticks and forestry populations in Inner Mongolia, China.Frontiers in public health · 2024Article
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- Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia.BMC microbiology · 2023Article
- Co-infection of tick-borne bacterial pathogens in ticks in Inner Mongolia, China.PLoS neglected tropical diseases · 2023Article
- Article
- Microbial diversity of ticks and a novel typhus group Rickettsia species (Rickettsiales bacterium Ac37b) in Inner Mongolia, China.Parasite (Paris, France) · 2023Article
- The life cycle ofFrontiers in veterinary science · 2023Article
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14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHard ticks act as arthropod vectors in the transmission of human and animal pathogens and are widely distributed in northern China. The aim of this study is to screen the important tick-borne pathogens (TBPs) carried by hard ticks in Inner Mongolia using metagenomic next-generation sequencing (mNGS) and to estimate the risk of human infection imposed by tick bites.
methodsThe adult Dermacentor nuttalli (n = 203) and Ixodes persulcatus (n = 36) ticks feeding on cattle were collected. The pooled DNA samples prepared from these ticks were sequenced as the templates for mNGS to survey the presence of TBPs at the genus level. Individual tick DNA samples were detected by genus--specific or group-specific nested polymerase chain reaction (PCR) of these TBPs and combined with DNA sequencing assay to confirm the results of mNGS.
resultsR. raoultii (45.32%, 92/203), Candidatus R. tarasevichiae (5.42%, 11/203), Anaplasma sp. Mongolia (26.60%, 54/203), Coxiella-like endosymbiont (CLE) (53.69%, 109/203), and Babesia venatorum (7.88%, 16/203) were detected in D. nuttalli, while R. raoultii (30.56%, 11/36), Anaplasma sp. Mongolia (27.80%, 10/36), and CLE (27.80%, 10/36) were detected in I. persulcatus. The double- and triple-pathogen/endosymbiont co-infections were detected in 40.39% of D. nuttalli and 13.89% of I. persulcatus, respectively. The dual co-infection with R. raoultii and CLE (14.29%, 29/203) and triple co-infection with R. raoultii, Anaplasma sp. Mongolia, and CLE (13.79%, 28/203) were most frequent in D. nuttalli.
conclusionsThis study provides insight into the microbial diversity of D. nuttalli and I. persulcatus in Inner Mongolia, China, reporting for the first time that Candidatus R. tarasevichiae had been found in D. nuttalli in China, and for the first time in the world that Anaplasma sp. Mongolia has been detected in I. persulcatus. This study proves that various vertically transmitted pathogens co-inhabit D. nuttalli and I. persulcatus, and indicates that cattle in Inner Mongolia are exposed to several TBPs.
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