Evidence map›Paper›PMID 34044756›Full record

ArticleThe journal of headache and pain2021

Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model.

K C Elina, Byeong Ho Oh, Jaisan Islam, Soochong Kim, Young Seok Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Optogenetics in oral and craniofacial research.Journal of Zhejiang University. Science. B · 2024
    Review
  6. Pain Relief in a Trigeminal Neuralgia ModelFrontiers in cellular neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

K C ElinaDepartment of Neuroscience, College of Medicine, Chungbuk National University, Cheongju, South Korea.
Byeong Ho OhDepartment of Neuroscience, College of Medicine, Chungbuk National University, Cheongju, South Korea.
Jaisan IslamDepartment of Neuroscience, College of Medicine, Chungbuk National University, Cheongju, South Korea.
Soochong KimDepartment of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea.
Young Seok ParkDepartment of Neuroscience, College of Medicine, Chungbuk National University, Cheongju, South Korea. youngseokparkmd@gmail.com.ORCID http://orcid.org/0000-0001-7685-6292
Chungbuk National University · KR

Funding

National Research Foundation of Korea 2020R1F1A1052716
6 · The paper itself

Abstract

backgroundPreceding studies have reported the association of chronic neuropathic orofacial pain with altered ongoing function in the ventrolateral periaqueductal gray (vlPAG). However, its role in trigeminal neuralgia (TN) lacks attention. We here reported the aspect that vlPAG neurons play in TN nociceptive processing by employing excitatory neuron-specific optogenetic approaches.

methodsTN was generated via unilateral infraorbital nerve chronic constriction in Sprague Dawley rats which induced mechanical and thermal pain sensitivity in air puff and acetone test, respectively. Channelrhodopsin conjugated virus with CamKIIα promoter was used to specifically activate the excitatory vlPAG neuronal population by optogenetic stimulation and in vivo microdialysis was done to determine its effect on the excitatory-inhibitory balance. In vivo extracellular recordings from ventral posteromedial (VPM) thalamus were assessed in response to vlPAG optogenetic stimulation. Depending on the experimental terms, unpaired student's t test and two-way analysis of variance (ANOVA) were used for statistical analysis.

resultsWe observed that optogenetic activation of vlPAG subgroup neurons markedly improved pain hypersensitivity in reflexive behavior tests which was also evident on microdialysis analysis with increase glutamate concentration during stimulation period. Decreased mean firing and burst rates were evident in VPM thalamic electrophysiological recordings during the stimulation period. Overall, our results suggest the optogenetic activation of vlPAG excitatory neurons in a TN rat model has pain ameliorating effect.

conclusionsThis article presents the prospect of pain modulation in trigeminal pain pathway via optogenetic activation of vlPAG excitatory neurons in rat model. This outlook could potentially assist vlPAG insight and its optogenetic approach in trigeminal neuropathic pain which aid clinicians endeavoring towards enhanced pain relief therapy in trigeminal neuralgia patients.

Indexed as

Periaqueductal GrayTrigeminal NeuralgiaAnimalsHumansNeuronsRatsRats, Sprague-DawleyThalamusMicrodialysisOptogeneticsPeriaqueductal grayThalamusTrigeminal neuralgia

Identifiers

PMID34044756
PMCPMC8161973
OpenAlexW3165116090

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.