Evidence map›Paper›PMID 34044577›Full record

ArticleCirculation. Heart failure2021

Exception Status Listing in the New Adult Heart Allocation System: A New Solution to an Old Problem?

Veli K Topkara, Kevin J Clerkin, Justin A Fried, Jan Griffin, Jayant Raikhelkar, Sun Hi Lee, Farhana Latif, Marlena Habal, Evelyn Horn, Maryjane A Farr and 5 more

Abstract read
In one paragraph

Article in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Association of high-priority exceptions with waitlist mortality among heart transplant candidates.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023
    Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Veli K TopkaraDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Kevin J ClerkinDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Justin A FriedDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Jan GriffinDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Jayant RaikhelkarDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Sun Hi LeeDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Farhana LatifDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Marlena HabalDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Evelyn HornDivision of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY (E.H., G.S., N.U.).
Maryjane A FarrDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Koji TakadaDivision of Cardiac, Thoracic, Vascular Surgery, Department of Surgery (K.T., Y.N.), Columbia University Irving Medical Center, New York, NY.
Yoshifumi NakaDivision of Cardiac, Thoracic, Vascular Surgery, Department of Surgery (K.T., Y.N.), Columbia University Irving Medical Center, New York, NY.
Ulrich P JordeDivision of Cardiology, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, New York, NY (U.P.J.).
Gabriel SayerDivision of Cardiology, Department of Medicine (V.K.T., K.J.C., J.A.F., J.G., J.R., S.H.L., F.L., M.H., M.A.F., G.S., N.U.), Columbia University Irving Medical Center, New York, NY.
Nir UrielDivision of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY (E.H., G.S., N.U.).

Funding

Identifying Novel Diagnostics and Mechanisms for Cardiac Allograft VasculopathyK23HL148528 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLERKIN, KEVIN J · 2020 to 2024
$852k
Defining the Role of lnc-TECRL in Maladaptive Cardiac RemodelingK08HL146964 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TOPKARA, VELI KEMAL · 2019 to 2022
$671k
NHLBI NIH HHS K08 HL146964NHLBI NIH HHS K23 HL148528
6 · The paper itself

Abstract

backgroundOne of the goals of the revised 6-tiered US adult heart allocation policy was to improve risk stratification of patients to lower exception status utilization for transplant listing. We sought to define the characteristics and outcomes of waitlisted patients using exception status and to examine region- and center-level differences in utilization of exception status in the new heart allocation system.

methodsThis retrospective cohort analysis of the United Network for Organ Sharing database included adult waitlisted patients for heart transplant between October 18, 2018, and June 30, 2020, in the United States, stratified by use of exception status versus standard criteria.

resultsOut of 6351 patients, 1907 (30.0%) were waitlisted under exception status. Patients using exception status were more likely to have a nonischemic cause of heart failure, blood type O, United Network for Organ Sharing status 2 at listing and were less likely to have a durable left ventricular assist device at listing. Exception status utilization varied significantly between and within United Network for Organ Sharing regions. Listing by exception criteria was associated with a significantly higher incidence of heart transplantation compared with listing by standard criteria (hazard ratio, 1.25 [1.15-1.38],

conclusionsThe status tiers of the new heart allocation system may not fully capture medical urgency and complexity of waitlisted patients as assessed by transplant physicians and review committees and may limit the ability to develop a heart allocation score.

Indexed as

Heart TransplantationPatient SelectionAdultDatabases, FactualFemaleHeart-Assist DevicesHeart FailureHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRegistriesRetrospective StudiesUnited Statesdeathguidelineheart failureheart transplantationmortality

Identifiers

PMID34044577
PMCPMC8218576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.