Evidence map›Paper›PMID 34043935›Full record

ArticlePharmaceutical biology2021

Cytotoxic furanosesquiterpenoids and steroids from

Fatemeh Heidary Jamebozorgi, Morteza Yousefzadi, Omidreza Firuzi, Melika Nazemi, Somayeh Zare, Jima N Chandran, Bernd Schneider, Ian T Baldwin, Amir Reza Jassbi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Marine drugs · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fatemeh Heidary JamebozorgiDepartment of Marine Biology, Faculty of Marine Sciences and Technology, University of Hormozgan, Bandar Abbas, Iran.
Morteza YousefzadiDepartment of Marine Biology, Faculty of Marine Sciences and Technology, University of Hormozgan, Bandar Abbas, Iran.
Omidreza FiruziMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Melika NazemiPersian Gulf and Oman Sea Ecological Research, Iranian Fisheries Research Institute, Agricultural Research, Education and Extension Organization, Bandar Abbas, Iran.
Somayeh ZareMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jima N ChandranResearch Group Biosynthesis/NMR, Max Planck Institute for Chemical Ecology, Jena, Germany.
Bernd SchneiderResearch Group Biosynthesis/NMR, Max Planck Institute for Chemical Ecology, Jena, Germany.
Ian T BaldwinDepartment of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany.
Amir Reza JassbiMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveOur objective was to characterise the cytotoxic constituents of two seasonal collections of MATERIALS AND

methodsThe sponges were extracted in methanol-dichloromethane and their constituents were purified and characterised using column chromatography, GC-MS, 1 D and 2 D NMR. Anti-proliferative activities of the compounds, were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay (0.25-100 μg/mL, 72 h) against leukaemia (MOLT-4), breast (MCF-7) and colon cancer (HT-29) human cells.

resultsThree furanosesquiterpoids; furodysin ( DISCUSSION AND

conclusionThe present study suggests that

Indexed as

AnimalsAntineoplastic AgentsBreast NeoplasmsCell Line, TumorColonic NeoplasmsFemaleHT29 CellsHumansInhibitory Concentration 50LeukemiaMCF-7 CellsPoriferaSesquiterpenesSteroidsAntineoplastic AgentsSesquiterpenesSteroidscholesterolergosterolFuranosesquiterpenesmarine spongestigmasterolγ-sitosterol

Identifiers

PMID34043935
PMCPMC8168774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.