Evidence map›Paper›PMID 34043881›Full record

ArticleAging cell2021

Regulatory KIR

Daan K J Pieren, Noortje A M Smits, Jeroen Hoeboer, Vinitha Kandiah, Rimke J Postel, Rob Mariman, Josine van Beek, Debbie van Baarle, Jelle de Wit, Teun Guichelaar

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Neuron-reactive KIRNature communications · 2025
    Article
  2. Article
  3. Bystander CD8Frontiers in immunology · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. KIR-HLA interactions extend human CD8+ T cell lifespan in vivo.The Journal of clinical investigation · 2023
    Article
  9. Negativity begets longevity in T cells.The Journal of clinical investigation · 2023
    Article
  10. Review
  11. Human CD8Immune network · 2023
    Review
  12. Review
  13. Virtual Memory CD8Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Review
  14. Article
  15. Review
  16. ReducedFrontiers in aging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Daan K J PierenCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.ORCID 0000-0003-0461-5064
Noortje A M SmitsCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Jeroen HoeboerCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Vinitha KandiahCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Rimke J PostelCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Rob MarimanCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Josine van BeekCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Debbie van BaarleCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Jelle de WitCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Teun GuichelaarCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.ORCID 0000-0002-5112-8923
National Institute for Public Health and the Environment · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe respiratory viral infectious diseases such as influenza and COVID-19 especially affect the older population. This is partly ascribed to diminished CD8

Indexed as

AgedAged, 80 and overAgingCD8-Positive T-LymphocytesCOVID-19FemaleGene Expression RegulationHumansInfluenza, HumanMaleMiddle AgedReceptors, KIRSARS-CoV-2T-Lymphocyte SubsetsReceptors, KIRagingCD8+ T cellskiller-cell immunoglobulin-like receptorsregulatory T cellsrespiratory viral infectionT-cell activationviral respiratory disease

Identifiers

PMID34043881
PMCPMC8208794
OpenAlexW3164211277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.