Evidence map›Paper›PMID 34043846›Full record

SynthesisInternational journal of geriatric psychiatry2021

Risk of dementia in patients with atrial fibrillation: Short versus long follow-up. A systematic review and meta-analysis.

Marco Zuin, Loris Roncon, Angelina Passaro, Cristina Bosi, Carlo Cervellati, Giovanni Zuliani

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of geriatric psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Non-Genetic Risk Factors of Alzheimer's Disease: An Updated Umbrella Review.The journal of prevention of Alzheimer's disease · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Brazilian Atrial Fibrillation Guidelines - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  7. Observational
  8. Review
  9. Article
  10. Review
  11. Design and deployment of the STEEER-AF trial to evaluate and improve guideline adherence: a cluster-randomized trial by the European Society of Cardiology and European Heart Rhythm Association.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  12. Bibliometric Insights Into the Evolution of Atrial Fibrillation and Dementia Research 2002-2022.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. The neurocognitive effects of atrial fibrillation: benefits of the ABC pathway.European heart journal. Cardiovascular pharmacotherapy · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marco ZuinDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Loris RonconDepartment of Cardiology, Santa Maria Delle Misericordia Hospital, Rovigo, Italy.
Angelina PassaroDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Cristina BosiDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Carlo CervellatiDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.ORCID 0000-0003-4777-6300
Giovanni ZulianiDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNo previous meta-analyses have compared the risk of dementia, due to an underlying atrial fibrillation (AF), in the short-term versus the long-term period.

aimTo perform an update meta-analysis of studies examining the association between AF and dementia and the relative impact of follow-up period.

methodsData were obtained searching MEDLINE and Scopus for all investigations published between 1 January 2000 and March 1, 2021 reporting the risk of dementia in AF patients. The following MeSH terms were used for the search: "Atrial Fibrillation" AND "Dementia" OR "Alzheimer's disease". From each study, the adjusted hazard ratio (aHR) with the related 95% confidence interval (CI) was pooled using a random effect model.

resultsThe analysis was carried out on 18 studies involving 3.559.349 subjects, of which 902.741 (25.3%) developed dementia during follow-up. A random effect model revealed an aHR of 1.40 (95% CI: 1.27-1.54, p < 0.0001; I

conclusionsEvidence suggests that patients with AF have an increased risk of developing dementia and AD. The risk of dementia was slightly higher when the follow-up was shorter than 10 years.

Indexed as

Atrial FibrillationDementiaFollow-Up StudiesHumansRisk Factorsatrial fibrillationdementiaelderlymeta-analysissystematic review

Identifiers

PMID34043846
PMCPMC8518611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.