Evidence map›Paper›PMID 34043837›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2021

Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data.

Nisha Venkatesh, Natalie Astbury, Merlin C Thomas, Carlos J Rosado, Evan Pappas, Balasubramanian Krishnamurthy, Richard J MacIsaac, Thomas W H Kay, Helen E Thomas, David N O'Neal

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Diabetes and SARS-CoV-2-Is There a Mutual Connection?Frontiers in cell and developmental biology · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Nisha VenkateshDepartment of Medicine, University of Melbourne, Fitzroy, Vic., Australia.
Natalie AstburyDepartment of Endocrinology and Diabetes, St. Vincent's Hospital Melbourne, Fitzroy, Vic., Australia.
Merlin C ThomasDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, Vic., Australia.
Carlos J RosadoDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, Vic., Australia.
Evan PappasSt. Vincent's Institute, Fitzroy, Vic., Australia.
Balasubramanian KrishnamurthyDepartment of Medicine, University of Melbourne, Fitzroy, Vic., Australia.
Richard J MacIsaacDepartment of Medicine, University of Melbourne, Fitzroy, Vic., Australia.
Thomas W H KayDepartment of Medicine, University of Melbourne, Fitzroy, Vic., Australia.
Helen E ThomasDepartment of Medicine, University of Melbourne, Fitzroy, Vic., Australia.
David N O'NealDepartment of Medicine, University of Melbourne, Fitzroy, Vic., Australia.ORCID 0000-0002-0870-4032
The University of Melbourne · AUMonash University · AUSt Vincent's Hospital Melbourne · AUSt Vincents Institute of Medical Research · AU

Funding

National Health and Medical Research Council of Australia GNT1126237National Health and Medical Research Council of Australia GNT1150425State Government of Victoria
6 · The paper itself

Abstract

aimsAim of this study is to report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, responsible for coronavirus disease 2019 (COVID-19), as a possible cause for type 1 diabetes by providing an illustrative clinical case of a man aged 45 years presenting with antibody-negative diabetic ketoacidosis post-recovery from COVID-19 pneumonia and to explore the potential for SARS-CoV-2 to adhere to human islet cells.

methodsExplanted human islet cells from three independent solid organ donors were incubated with the SARS-CoV-2 spike protein receptor biding domain (RBD) fused to a green fluorescent protein (GFP) or a control-GFP, with differential adherence established by flow cytometry.

resultsFlow cytometry revealed dose-dependent specific binding of RBD-GFP to islet cells when compared to control-GFP.

conclusionsAlthough a causal basis remains to be established, our case and in vitro data highlight a potential mechanism by which SARS-CoV-2 infection may result in antibody-negative type 1 diabetes.

Indexed as

COVID-19Diabetes Mellitus, Type 1Diabetic KetoacidosisHumansIn Vitro TechniquesIslets of LangerhansMaleMiddle AgedSARS-CoV-2Spike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19critical carediabetic ketoacidosisislets of LangerhanspneumoniaSARS-CoV-2type 1 diabetes

Identifiers

PMID34043837
PMCPMC8236964
OpenAlexW3164154912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.