ArticlePloS one2021
Prevalence of and risk factors for post-intensive care syndrome: Multicenter study of patients living at home after treatment in 12 Japanese intensive care units, SMAP-HoPe study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis.Journal of the neurological sciences · 2022Pooled it
- Critical care delirium: prevention, identification and management: a narrative review.Anaesthesia · 2026Review
- Cross-cultural adaptation and validation of the Korean version of the Post-Intensive Care Syndrome Knowledge Test (K-PICS-KT): a methodological study.Journal of Korean biological nursing science · 2026Article
- Early Sedation Intensity and Psychological Outcomes in Critically Ill Adults.Nursing in critical care · 2026Article
- Discharge-time prediction of 1-month posttraumatic stress symptom severity (PCL-5) after mechanical ventilation using a dual-attention 1D-CNN: Development and validation.PLOS mental health · 2026Article
- Nursing Intervention to Support Psychological Recovery Among Intensive Care Patients and Their Families: A Systematic Review with Narrative Synthesis.Journal of multidisciplinary healthcare · 2026Review
- Long-term mental health change patterns in ICU survivors: a four-year comparative follow-up from the SMAP-HoPe study.Journal of intensive care · 2025Article
- Article
- Post-Intensive Care Syndrome as a Burden for Patients and Their Caregivers: A Narrative Review.Journal of clinical medicine · 2024Review
- Beyond survival: understanding post-intensive care syndrome.Acute and critical care · 2024Article
- Review
- Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study.Journal of intensive care · 2023Article
- Appetite loss and associated factors at 1 year after intensive care unit elder survivors in a secondary analysis of the SMAP-HoPe study.Scientific reports · 2023Article
- Post-Intensive Care Syndrome-10 Years after Its Proposal and Future Directions.Journal of clinical medicine · 2022Article
- Employment status and its associated factors for patients 12 months after intensive care: Secondary analysis of the SMAP-HoPe study.PloS one · 2022Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies have examined the epidemiology of post-intensive care syndrome in Japan. This study investigated the mental health and quality of life of patients living at home in Japan after intensive care unit (ICU) discharge. Additionally, we examined whether unplanned admission to the ICU was associated with more severe post-traumatic stress disorder (PTSD), anxiety, and depressive symptoms. An ambidirectional cohort study was conducted at 12 ICUs in Japan. Patients who stayed in the ICU for > 3 nights and were living at home for 1 year afterward were included. One year after ICU discharge, we retrospectively screened patients and performed a mail survey on a monthly basis, including the Impact of Event Scale-Revised (IER-S), the Hospital Anxiety Depression Scale (HADS), and the EuroQOL-5 Dimension (EQ-5D-L) questionnaires. Patients' characteristics, delirium and coma status, drugs used, and ICU and hospital length of stay were assessed from medical records. Descriptive statistics and multilevel linear regression modeling were used to examine our hypothesis. Among 7,030 discharged patients, 854 patients were surveyed by mail. Of these, 778 patients responded (response rate = 91.1%). The data from 754 patients were analyzed. The median IES-R score was 3 (interquartile range [IQR] = 1‒9), and the prevalence of suspected PTSD was 6.0%. The median HADS anxiety score was 4.00 (IQR = 1.17‒6.00), and the prevalence of anxiety was 16.6%. The median HADS depression score was 5 (IQR = 2‒8), and the prevalence of depression was 28.1%. EQ-5D-L scores were lower in our participants than in the sex- and age-matched Japanese population. Unplanned admission was an independent risk factor for more severe PTSD, anxiety, and depressive symptoms. Approximately one-third of patients in the general ICU population experienced mental health issues one year after ICU discharge. Unplanned admission was an independent predictor for more severe PTSD symptoms.
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