ArticlePloS one2021
Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Center of mass feedback for joint torque control during perturbed standing: a potential generalizable control approach for balance augmentation in wearable robots.Journal of neuroengineering and rehabilitation · 2026Article
- Article
- Characterization of Human Balance through a Reinforcement Learning-based Muscle Controller.PloS one · 2025Article
- Center of mass states render multijoint torques throughout standing balance recovery.Journal of neurophysiology · 2025Article
- The Effects of Adapted Tango on Dynamic Balance and Dual-Task Performance in Parkinson's Disease.Journal of motor behavior · 2025Article
- Combined translational and rotational perturbations of standing balance reveal contributions of reduced reciprocal inhibition to balance impairments in children with cerebral palsy.PLoS computational biology · 2024Article
- Precise cortical contributions to sensorimotor feedback control during reactive balance.PLoS computational biology · 2024Article
- Imbalance and gait impairment in Parkinson's disease: discussing postural instability and ataxia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Article
- Increased muscle responses to balance perturbations in children with cerebral palsy can be explained by increased sensitivity to center of mass movement.Gait & posture · 2024Article
- Assisting walking balance using a bio-inspired exoskeleton controller.Journal of neuroengineering and rehabilitation · 2023Article
- Voluntary muscle coactivation in quiet standing elicits reciprocal rather than coactive agonist-antagonist control of reactive balance.Journal of neurophysiology · 2023Article
- Dopamine replacement therapy normalizes reactive step length to postural perturbations in Parkinson's disease.Gait & posture · 2023Article
- Exoskeletons need to react faster than physiological responses to improve standing balance.Science robotics · 2023Article
- The cortical N1 response to balance perturbation is associated with balance and cognitive function in different ways between older adults with and without Parkinson's disease.Cerebral cortex communications · 2022Article
- Lower Cognitive Set Shifting Ability Is Associated With Stiffer Balance Recovery Behavior and Larger Perturbation-Evoked Cortical Responses in Older Adults.Frontiers in aging neuroscience · 2021Article
- Cortical Beta Oscillatory Activity Evoked during Reactive Balance Recovery Scales with Perturbation Difficulty and Individual Balance Ability.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although Parkinson disease (PD) causes profound balance impairments, we know very little about how PD impacts the sensorimotor networks we rely on for automatically maintaining balance control. In young healthy people and animals, muscles are activated in a precise temporal and spatial organization when the center of body mass (CoM) is unexpectedly moved that is largely automatic and determined by feedback of CoM motion. Here, we show that PD alters the sensitivity of the sensorimotor feedback transformation. Importantly, sensorimotor feedback transformations for balance in PD remain temporally precise, but become spatially diffuse by recruiting additional muscle activity in antagonist muscles during balance responses. The abnormal antagonist muscle activity remains precisely time-locked to sensorimotor feedback signals encoding undesirable motion of the body in space. Further, among people with PD, the sensitivity of abnormal antagonist muscle activity to CoM motion varies directly with the number of recent falls. Our work shows that in people with PD, sensorimotor feedback transformations for balance are intact but disinhibited in antagonist muscles, likely contributing to balance deficits and falls.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.