Evidence map›Paper›PMID 34043464›Full record

ArticlePsychological science2021

Undetected Neurodegenerative Disease Biases Estimates of Cognitive Change in Older Adults.

Karra D Harrington, Andrew J Aschenbrenner, Paul Maruff, Colin L Masters, Anne M Fagan, Tammie L S Benzinger, Brian A Gordon, Carlos Cruchaga, John C Morris, Jason Hassenstab

Open access · greenAbstract read
In one paragraph

Article in Psychological science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Dissociable Effects of Alzheimer's Disease-Related Cognitive Dysfunction and Aging on Functional Brain Network Segregation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neuropsychological Correlates of Changes in Driving Behavior Among Clinically Healthy Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Karra D HarringtonThe Florey Institute, The University of Melbourne.
Andrew J AschenbrennerCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis.
Paul MaruffThe Florey Institute, The University of Melbourne.
Colin L MastersThe Florey Institute, The University of Melbourne.
Anne M FaganCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis.
Tammie L S BenzingerCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis.
Brian A GordonCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis.
Carlos CruchagaDepartment of Psychiatry, Washington University in St. Louis.
John C MorrisCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis.
Jason HassenstabCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis.ORCID 0000-0002-7802-3371
Washington University in St. Louis · USThe University of Melbourne · AUPennsylvania State University · US

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
PURCHASE OF A SIEMENS NEXT GENERATION PET/CTS10OD025214 · OD · WASHINGTON UNIVERSITY · PI WOODARD, PAMELA K · 2018 to 2018
$2.0M
NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIH HHS S10 OD025214
6 · The paper itself

Abstract

Neurodegenerative disease is highly prevalent among older adults and, if undetected, may obscure estimates of cognitive change among aging samples. Our aim in this study was to determine the nature and magnitude of cognitive change in the absence of common neuropathologic markers of neurodegenerative disease. Cognitively normal older adults (ages 65-89 years,

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesAgedAged, 80 and overAmyloid beta-PeptidesBiasBiomarkersCognitionHumansMemoryNeuropsychological TestsAmyloid beta-PeptidesBiomarkerscognitive agingmemoryneurodegenerationprocessing speedtauβ-amyloid

Identifiers

PMID34043464
PMCPMC8726587
OpenAlexW3164969782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.