Evidence map›Paper›PMID 34043421›Full record

ArticleCirculation research2021

NAD Repletion Therapy: A Silver Bullet for HFpEF?

Fadi G Akar, Lawrence H Young

Abstract readEditorialComment
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. NADInternational journal of medical sciences · 2024
    Review
  3. Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

  • Comment on
    NAD2021
5 · Who and what money

Authors and funding

2 authors.

Fadi G AkarInternal Medicine (Cardiovascular) (F.G.A., L.H.Y.), Yale School of Medicine, New Haven, CT.
Lawrence H YoungInternal Medicine (Cardiovascular) (F.G.A., L.H.Y.), Yale School of Medicine, New Haven, CT.

Funding

Metabolic signaling in atrial fibrillation and remodelingR01HL148008 · NHLBI · YALE UNIVERSITY · PI AKAR, FADI GABRIEL, YOUNG, LAWRENCE H · 2021 to 2024
$2.2M
Molecular Determinants of Mitochondrial Instability and ArrhythmiasR01HL137259 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AKAR, FADI GABRIEL, O'ROURKE, BRIAN · 2017 to 2020
$2.0M
Mitochondrial fission in diabetes-related arrhythmiaR01HL149344 · NHLBI · YALE UNIVERSITY · PI AKAR, FADI GABRIEL · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL137259NHLBI NIH HHS R01 HL148008NHLBI NIH HHS R01 HL149344
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Heart FailureHumansNADObesityStroke VolumeNADEditorialsheart failuremetabolismmitochondriaobesity

Identifiers

PMID34043421
PMCPMC8513806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.