ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060).
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 788 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)
Alzheimer's National Registry for Treatment and Diagnostics
Who cites it
788 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- Racial and Ethnic Reporting and Representation in US Alzheimer Clinical Trials: A Systematic Review.JAMA network open · 2026Pooled it
- Motor Learning in Older Adults with Mild Cognitive Impairment: A Systematic Review.Neuropsychology review · 2026Pooled it
- How do existing HRSN assessment tools assess social needs for older adults? A systematic review.Frontiers in health services · 2026Pooled it
- Viral infections and the risk of neurodegenerative diseases: a comprehensive meta-analysis and systematic review.Translational psychiatry · 2025Pooled it
- Matrix metalloproteinase-9 is associated with CX3CL1 on tau and amyloid biomarker pathways in APOE4 carriers.Neurobiology of disease · 2026Trial
- Effects of one avocado a day for six months on cognitive performance in overweight adults: A randomized controlled trial.The journal of nutrition, health & aging · 2026Trial
- Intranasal drug delivery to the brain for neurodegenerative diseases: Current efforts and challenges in delivery platforms and modeling.Advanced drug delivery reviews · 2026Review
- The interplay between vitamin D3 and Nrf2 signaling: mechanistic insights and therapeutic potentials.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- The effects of improved access to diabetes medications on risk of Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Racial Climate on Willingness to Participate in Clinical Research.Journal of racial and ethnic health disparities · 2026Article
- Sensory Difficulty, Social and Physical Activity, and Dementia Risk Among Older Adults.Journal of aging and health · 2026Article
- Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Numeracy and recall of Alzheimer's disease risk information: Effects of risk format in a Latino community.Patient education and counseling · 2026Article
- Women's musculoskeletal health: insights from the 2024 National Academies of Sciences, Engineering, and Medicine report on chronic conditions.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Review
- Associations of Brain Structure and Neuropsychological Function With Artificial Intelligence Estimates of Biological Vascular Age.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Prevalence, risk factors, and racial disparities in probable and possible dementia: the national health and aging trends study.The journal of prevention of Alzheimer's disease · 2026Article
- A Cross-Region Meta-Analysis and Machine Learning Identifies a 37-Gene Signature Associated with Alzheimer's Disease.Biomedicines · 2026Article
- Identification of prevalent dementia in Medicare Advantage encounters, compared with rigorous cohort assessments.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
728 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionThe estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.
methodsWe estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores.
resultsThe 2020 US Census-adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7-11.9): 10.0% among non-Hispanic Whites, 14.0% among Hispanics, and 18.6% among non-Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75-6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98-14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men. DISCUSSION: The number of people with clinical AD will increase as the "baby boom" generation reaches older ages, exerting a strong upward influence on disease burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.