ReviewChembiochem : a European journal of chemical biology2021
Recent Advances in Bioactive Artificial Ionophores.
Review in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels.Angewandte Chemie (International ed. in English) · 2026Article
- Spatiotemporal Control of the Formation of Luminescent Lanthanide Complexes in Liposome-Based Nanoreactors.Angewandte Chemie (International ed. in English) · 2025Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- A Single-Molecule Liposome Assay for Membrane Permeabilization.Angewandte Chemie (International ed. in English) · 2025Article
- Synthesis and Reactivity of Oligo(ethylene glycol)-Tethered Morita-Baylis-Hillman Dimers in the Formation of Macrocyclic Structures Showing Remarkable Cytotoxicity.Pharmaceuticals (Basel, Switzerland) · 2025Article
- A non-B DNA binding peptidomimetic channel alters cellular functions.Nature communications · 2024Article
- Unveiling the potent activity of a synthetic ion transporter against multidrug-resistant Gram-positive bacteria and biofilms.RSC medicinal chemistry · 2024Article
- New Polyether Macrocycles as Promising Antitumor Agents-Targeted Synthesis and Induction of Mitochondrial Apoptosis.ACS omega · 2024Article
- An Exceptionally Active and Highly Selective Perchlorate Transporter Containing a Trimesic Amide Scaffold.Molecules (Basel, Switzerland) · 2024Article
- Wearing the Lab: Advances and Challenges in Skin-Interfaced Systems for Continuous Biochemical Sensing.Advances in biochemical engineering/biotechnology · 2024Review
- Small molecule anion carriers facilitate lactate transport in model liposomes and cells.iScience · 2023Article
- Transmembrane transport of fluoride studied by time-resolved emission spectroscopy.Chemical communications (Cambridge, England) · 2023Article
- Hitchhiking into a cell: flavonoids may produce complexes with transition metals for transmembrane translocation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Dynamic Covalent Self-Assembly of Chloride- and Ion-Pair-Templated Cryptates.Angewandte Chemie (International ed. in English) · 2022Article
- Rational Design of Silicon-Based Zinc Ionophores.Angewandte Chemie (International ed. in English) · 2022Article
- Calix[6]arenes with halogen bond donor groups as selective and efficient anion transporters.Chemical communications (Cambridge, England) · 2022Article
- Organoplatinum Compounds as Anion-Tuneable Uphill Hydroxide Transporters.Angewandte Chemie (International ed. in English) · 2022Article
- Ion Channels and Transporters as Therapeutic Agents: From Biomolecules to Supramolecular Medicinal Chemistry.Biomedicines · 2022Review
- Recent Advances in Bioactive Artificial Ionophores.Chembiochem : a European journal of chemical biology · 2021Review
- Supramolecular chemistry in lipid bilayer membranes.Chemical science · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Several life-threatening diseases, also known as 'Channelopathies' are linked to irregularities in ion transport proteins. Significant research efforts have fostered the development of artificial transport systems that facilitates to restore the functions of impaired natural transport proteins. Indeed, a few of these artificial ionophores demonstrate the rare combination of transmembrane ion transport and important biological activity, offering early promises of suitability in 'channel replacement therapy'. In this review, structural facets and functions of both cationophores and anionophores are discussed. Ionophores that are toxic to various bacteria and yeast, could be exploited as antimicrobial agent. Nevertheless, few non-toxic ionophores offer the likelihood of treating a wide range of genetic diseases caused by the gene mutations. In addition, their ability to disrupt cellular homeostasis and to alter lysosomal pH endow ionophores as promising candidates for cancer treatment. Overall, critically outlining the advances in artificial ionophores in terms of in vitro ion transport, possible modes of action and biological activities enables us to propose possible future roadmaps in this research area.
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Registered trials
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