Evidence map›Paper›PMID 34043151›Full record

SynthesisJournal of thrombosis and thrombolysis2022

Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation.

Shuai Yuan, Maria Bruzelius, Susanna C Larsson

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Kidney Function Measures and Mortality: A Mendelian Randomization Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Shuai YuanUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobelsväg 13, 17177, Stockholm, Sweden.
Maria BruzeliusCoagulation Unit, Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.
Susanna C LarssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobelsväg 13, 17177, Stockholm, Sweden. susanna.larsson@ki.se.ORCID http://orcid.org/0000-0003-0118-0341
Karolinska Institutet · SEKarolinska University Hospital · SEUppsala University · SE

Funding

Forskningsrådet om Hälsa, Arbetsliv och Välfärd 2018-00123Hjärt-Lungfonden 20190247Stockholms Läns Landsting K2892-2016Vetenskapsrådet 2019-00977
6 · The paper itself

Abstract

Whether renal function is causally associated with venous thromboembolism (VTE) is not yet fully elucidated. We conducted a two-sample Mendelian randomization (MR) study to determine the causal effect of renal function, measured as estimated glomerular filtration rate (eGFR), on VTE. Single-nucleotide polymorphisms associated with eGFR were selected as instrumental variables at the genome-wide significance level (p < 5 × 10

Indexed as

Venous ThromboembolismGenome-Wide Association StudyGlomerular Filtration RateHumansKidneyMendelian Randomization AnalysisPolymorphism, Single NucleotideEstimated glomerular filtration rateMendelian randomization analysisRenal functionVenous thromboembolism

Identifiers

PMID34043151
PMCPMC8791872
OpenAlexW3164687163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.