Evidence map›Paper›PMID 34043146›Full record

ArticleLa Radiologia medica2021

CT radiomic models to distinguish COVID-19 pneumonia from other interstitial pneumonias.

Nicolò Cardobi, Giulio Benetti, Giuseppe Cardano, Cinzia Arena, Claudio Micheletto, Carlo Cavedon, Stefania Montemezzi

Abstract read
In one paragraph

Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Exploring Radiologists' Burnout in the COVID-19 Era: A Narrative Review.International journal of environmental research and public health · 2023
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  17. A review on advances inInsights into imaging · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicolò Cardobi *Department of Pathology and Diagnostics, Radiology Unit, Azienda Ospedaliera Universitaria Integrata, P.le Stefani 1, 37126, Verona, Italy.ORCID http://orcid.org/0000-0001-7856-3442
Giulio Benetti *Department of Pathology and Diagnostics, Medical Physics Unit, Azienda Ospedaliera Universitaria Integrata, P.le Stefani 1, 37126, Verona, Italy.ORCID http://orcid.org/0000-0002-7070-0083
Giuseppe CardanoDepartment of Pathology and Diagnostics, Radiology Unit, Azienda Ospedaliera Universitaria Integrata, P.le Stefani 1, 37126, Verona, Italy.ORCID http://orcid.org/0000-0002-6209-3973
Cinzia ArenaCardiovascular and Thoracic Department, Pneumology Unit, Azienda Ospedaliera Universitaria Integrata, P.le Stefani 1, 37126, Verona, Italy.
Claudio MichelettoCardiovascular and Thoracic Department, Pneumology Unit, Azienda Ospedaliera Universitaria Integrata, P.le Stefani 1, 37126, Verona, Italy.ORCID http://orcid.org/0000-0002-1138-3882
Carlo CavedonDepartment of Pathology and Diagnostics, Medical Physics Unit, Azienda Ospedaliera Universitaria Integrata, P.le Stefani 1, 37126, Verona, Italy. carlo.cavedon@aovr.veneto.it.ORCID http://orcid.org/0000-0001-7710-4607
Stefania MontemezziDepartment of Pathology and Diagnostics, Radiology Unit, Azienda Ospedaliera Universitaria Integrata, P.le Stefani 1, 37126, Verona, Italy.ORCID http://orcid.org/0000-0003-0216-2954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo classify COVID-19, COVID-19-like and non-COVID-19 interstitial pneumonia using lung CT radiomic features. MATERIAL AND

methodsCT data of 115 patients with respiratory symptoms suspected for COVID-19 disease were retrospectively analyzed. Based on the results of nasopharyngeal swab, patients were divided into two main groups, COVID-19 positive (C +) and COVID-19 negative (C-), respectively. C- patients, however, presented with interstitial lung involvement. A subgroup of C-, COVID-19-like (CL), were considered as highly suggestive of COVID pneumonia at CT. Radiomic features were extracted from the whole lungs. A dual machine learning (ML) model approach was used. The first one excluded CL patients from the training set, eventually included on the test set. The second model included the CL patients also in the training set.

resultsThe first model classified C + and C- pneumonias with AUC of 0.83. CL median response (0.80) was more similar to C + (0.92) compared to C- (0.17). Radiomic footprints of CL were similar to the C + ones (possibly false negative swab test). The second model, however, merging C + with CL patients in the training set, showed a slight decrease in classification performance (AUC = 0.81).

conclusionWhole lung ML models based on radiomics can classify C + and C- interstitial pneumonia. This may help in the correct management of patients with clinical and radiological stigmata of COVID-19, however presenting with a negative swab test. CL pneumonia was similar to C + pneumonia, albeit with slightly different radiomic footprints.

Indexed as

Tomography, X-Ray ComputedAdultAgedAged, 80 and overCOVID-19Diagnosis, DifferentialFemaleHumansLung Diseases, InterstitialMaleMiddle AgedModels, TheoreticalRetrospective StudiesCOVID-19LungMachine LearningPneumoniaTomographyViralX-Ray Computed

Identifiers

PMID34043146
PMCPMC8155795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.