Evidence map›Paper›PMID 34043140›Full record

ArticleNeurochemical research2021

Volatile Anesthetic Sevoflurane Precursor 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFIP) Exerts an Anti-Prion Activity in Prion-Infected Culture Cells.

Takuto Shimizu, Emiko Nogami, Yuka Ito, Kazuo Morikawa, Masaki Nagane, Tadashi Yamashita, Tsuyoshi Ogawa, Fuyuki Kametani, Hisashi Yagi, Naomi Hachiya

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Takuto ShimizuLaboratory of Biochemistry, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa, 252-5201, Japan.
Emiko NogamiChemical Research Center, Central Glass Co., Ltd., 17-5, Nakadai 2, Kawagoe City, Saitama, 350-1159, Japan.
Yuka ItoFaculty of Engineering, Tottori University, 4-101 Koyama-Minami, Tottori, 680-8552, Japan.
Kazuo MorikawaTokyo Metropolitan Industrial Technology Research Institute, 2-4-10 Aomi, Koto-Ku, Tokyo, 135-0064, Japan.
Masaki NaganeLaboratory of Biochemistry, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa, 252-5201, Japan.
Tadashi YamashitaLaboratory of Biochemistry, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa, 252-5201, Japan.
Tsuyoshi OgawaChemicals Business Development Department, Central Glass Co., Ltd, Kowa-Hitotsubashi Building, 7-1 Kanda-Nishikicho 3, Chiyoda-ku, Tokyo, 101-0054, Japan.
Fuyuki KametaniTokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-Ku, Tokyo, 156-8506, Japan.
Hisashi YagiFaculty of Engineering, Tottori University, 4-101 Koyama-Minami, Tottori, 680-8552, Japan.
Naomi HachiyaTokyo Metropolitan Industrial Technology Research Institute, 2-4-10 Aomi, Koto-Ku, Tokyo, 135-0064, Japan. naomi.hachiya@cgco.co.jp.ORCID http://orcid.org/0000-0003-1630-663X
Tokyo Metropolitan Industrial Technology Research Institute · JPAzabu University · JPCentral Glass (Japan) · JPTottori University · JPTokyo Metropolitan Institute of Medical Science · JP

Funding

Japan Society for the Promotion of Science JP19K2252
6 · The paper itself

Abstract

Prion disease is a neurodegenerative disorder with progressive neurologic symptoms and accelerated cognitive decline. The causative protein of prion disease is the prion protein (PrP), and structural transition of PrP from the normal helix rich form (PrP

Indexed as

AnimalsCell Line, TumorCell SurvivalChlorocebus aethiopsCOS CellsHydrocarbons, FluorinatedMicePrion ProteinsPropanolsProtein MultimerizationhexafluoroisopropanolHydrocarbons, FluorinatedPrion ProteinsPropanolsAmyloidAmyloid-beta (Aβ)Anti-prion drugHexafluoro isopropanolNeurodegenerationNeurodegenerative diseasePrionPrion diseasePrion protein

Identifiers

PMID34043140
PMCPMC8254714
OpenAlexW3164744276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.