Evidence map›Paper›PMID 34043128›Full record

ReviewJournal of autism and developmental disorders2021

Looking Back at the Next 40 Years of ASD Neuroscience Research.

James C McPartland, Matthew D Lerner, Anjana Bhat, Tessa Clarkson, Allison Jack, Sheida Koohsari, David Matuskey, Goldie A McQuaid, Wan-Chun Su, Dominic A Trevisan

Open access · greenAbstract readReview
In one paragraph

Review in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Review
  8. Article
  9. Molecular psychiatry · 2025
    Article
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  15. Article
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  19. Review
  20. ASD-Time for a paradigm shift.Frontiers in psychiatry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

James C McPartlandChild Study Center, Yale School of Medicine, New Haven, CT, 06520, USA. james.mcpartland@yale.edu.ORCID http://orcid.org/0000-0002-2570-0746
Matthew D LernerDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA.
Anjana BhatDepartment of Physical Therapy, University of Delaware, Newark, DE, USA.
Tessa ClarksonDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Allison JackDepartment of Psychology, George Mason University, Fairfax, VA, USA.
Sheida KoohsariDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Goldie A McQuaidDepartment of Psychology, George Mason University, Fairfax, VA, USA.
Wan-Chun SuDepartment of Physical Therapy, University of Delaware, Newark, DE, USA.
Dominic A TrevisanChild Study Center, Yale School of Medicine, New Haven, CT, 06520, USA.
Yale University · USGeorge Mason University · USUniversity of Delaware · USStony Brook University · USTemple University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Autism Biomarkers Consortium for Clinical TrialsU19MH108206 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2015 to 2024
$68.8M
Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Neural Mechanisms for Social Interactions and Eye Contact in ASDR01MH111629 · NIMH · YALE UNIVERSITY · PI HIRSCH, JOY, MCPARTLAND, JAMES CHARLES · 2016 to 2020
$3.2M
Investigating Social Competence in Youth with Autism: A Multisite RCTR01MH114906 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CORBETT, BLYTHE ANNE · 2018 to 2021
$3.0M
Optimizing Prediction of Social Deficits in Autism Spectrum DisordersR01MH110585 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI LERNER, MATTHEW DANIEL · 2016 to 2020
$2.2M
Neural markers of shared gaze during simulated social interactions in ASDR01MH100173 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2013 to 2015
$1.3M
Multimodel Assessment of Social Process Systems across Neurodevelopmental DisordersR01MH107426 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES, SRIHARI, VINOD H. · 2015 to 2017
$651k
Social-communicative deficits in Autism Spectrum Disorder as measured by mGluR5 positron emission tomographyR21MH113955 · NIMH · YALE UNIVERSITY · PI MATUSKEY, DAVID A, MCPARTLAND, JAMES CHARLES · 2018 to 2019
$461k
Adapting Biomarker Assays for Individuals with Autism and Intellectual DisabilityR21MH122202 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES, NAPLES, ADAM JOHN · 2019 to 2020
$461k
Biomarker Qualification Plan Development for the Oculomotor Index of Gaze to Human FacesU01FD007000 · FDA · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2020 to 2020
$249k
American Psychological Association Dissertation Research AwardAutism Speaks POID 11808Brain and Behavior Research Foundation ID 27542FDA HHS U01 FD007000NCATS NIH HHS UL1 TR001863NICHD NIH HHS R03 HD100771NIGMS NIH HHS P20 GM103446NIH HHS F31MH122091NIMH NIH HHS F31 MH122091NIMH NIH HHS R01 MH100028NIMH NIH HHS R01 MH100173NIMH NIH HHS R01 MH107426NIMH NIH HHS R01 MH110585NIMH NIH HHS R01 MH111629NIMH NIH HHS R01 MH114906NIMH NIH HHS R21 MH113955NIMH NIH HHS R21 MH122202NIMH NIH HHS U19 MH108206
6 · The paper itself

Abstract

During the last 40 years, neuroscience has become one of the most central and most productive approaches to investigating autism. In this commentary, we assemble a group of established investigators and trainees to review key advances and anticipated developments in neuroscience research across five modalities most commonly employed in autism research: magnetic resonance imaging, functional near infrared spectroscopy, positron emission tomography, electroencephalography, and transcranial magnetic stimulation. Broadly, neuroscience research has provided important insights into brain systems involved in autism but not yet mechanistic understanding. Methodological advancements are expected to proffer deeper understanding of neural circuitry associated with function and dysfunction during the next 40 years.

Indexed as

Autism Spectrum DisorderBrainElectroencephalographyHumansMagnetic Resonance ImagingTranscranial Magnetic StimulationAutism spectrum disorderEEGfNIRSMRINeuroimagingPETTMS

Identifiers

PMID34043128
PMCPMC8542594
OpenAlexW3165871611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.