Evidence map›Paper›PMID 34043076›Full record

ArticleBrain structure & function2021

Motor network connectivity predicts neuroplastic response following theta burst stimulation in healthy adults.

Brenton Hordacre, Mitchell R Goldsworthy, Lynton Graetz, Michael C Ridding

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05487885 (Anhedonia, Development, and Emotions), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05487885 phase4completednot on this mapstarted 2022, after this paper: background citation

Anhedonia, Development, and Emotions: Phenotyping and Therapeutics (ADEPT) Study

TypeinterventionalSponsorErika ForbesRan2022 to 2025Enrolled123ConditionsDepression, AnhedoniaArmsContinuous theta burst stimulation (cTBS), Positive Affect Training, Ketamine Injectable Solution
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brenton HordacreInnovation, Implementation and Clinical Translation (IIMPACT) in Health, University of South Australia, City East Campus, GPO Box 2471, Adelaide, South, 5001, Australia. brenton.hordacre@unisa.edu.au.ORCID http://orcid.org/0000-0002-7129-6684
Mitchell R GoldsworthyLifespan Human Neurophysiology Group, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Lynton GraetzLifespan Human Neurophysiology Group, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Michael C RiddingInnovation, Implementation and Clinical Translation (IIMPACT) in Health, University of South Australia, City East Campus, GPO Box 2471, Adelaide, South, 5001, Australia.

Funding

National Health and Medical Research Council 1102272National Health and Medical Research Council 1125054Physiotherapy Research Foundation S15-009
6 · The paper itself

Abstract

A patterned repetitive transcranial magnetic stimulation protocol, known as continuous theta burst stimulation (cTBS), can suppress corticospinal excitability via mechanisms that appear similar to long-term depression synaptic plasticity. Despite much potential, this technique is currently limited by substantial response variability. The purpose of this study was to investigate whether baseline resting state functional connectivity is a determinant of response to cTBS. Eighteen healthy young adults participated in up to three experimental sessions. Single-pulse transcranial magnetic stimulation was used to quantify change in corticospinal excitability following cTBS. Three minutes of resting electroencephalographic activity was recorded, and functional connectivity was estimated using the debiased weighted phase lag index across different frequency bands. Partial least squares regression identified models of connectivity between a seed region (C3) and the whole scalp that maximally accounted for variance in cTBS responses. There was no group-level effect of a single cTBS train or spaced cTBS trains on corticospinal excitability (p = 0.092). A low beta frequency band model of connectivity accounted for the largest proportion of variance in spaced cTBS response (R

Indexed as

Neuronal PlasticityTranscranial Magnetic StimulationElectroencephalographyEvoked Potentials, MotorHumansMotor CortexElectroencephalographyFunctional connectivityMotor cortexPlasticityTheta burst stimulationTranscranial magnetic stimulation

Identifiers

PMID34043076

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.