Evidence map›Paper›PMID 34043048›Full record

ArticleInternational urogynecology journal2022

Preoperative level II/III MRI measures predicting long-term prolapse recurrence after native tissue repair.

Payton Schmidt, Luyun Chen, John O DeLancey, Carolyn W Swenson

Erratum issuedAbstract read
In one paragraph

Article in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  3. [Application of Magnetic Resonance Imaging in the Diagnosis and Treatment of Middle Compartment Defect].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Payton SchmidtDepartment of Obstetrics and Gynecology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA. payton@med.umich.edu.ORCID http://orcid.org/0000-0002-9077-0409
Luyun ChenDepartment of Obstetrics and Gynecology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
John O DeLanceyDepartment of Obstetrics and Gynecology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
Carolyn W SwensonDepartment of Obstetrics and Gynecology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.

Funding

Which pelvic floor defects cause stress incontinence?P50HD044406 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DELANCEY, JOHN O.L. · 2002 to 2017
$17.1M
Mechanisms of anterior vaginal wall support failureR01HD038665 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DELANCEY, JOHN O.L. · 2000 to 2014
$3.8M
University of Michigan WRHR Career Development ProgramK12HD065257 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FENNER, DEE ELLEN · 2010 to 2019
$3.4M
Using a mechanistic classification scheme to identify the causes of anterior vaginal wall prolapse and develop a validated surgical planning systemR01HD094954 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, LUYUN · 2018 to 2020
$935k
Interaction of pre-operative structural failure sites and operative repair strategies in prolapse: A biomechanical modeling approachR21HD079908 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, LUYUN · 2015 to 2016
$386k
Failure Phenotyping: Functional Anatomy-Based Prediction of Pelvic Organ Prolapse RecurrenceR03HD096189 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWENSON, CAROLYN W · 2019 to 2020
$156k
NICHD NIH HHS K12 HD065257NICHD NIH HHS P50 HD044406NICHD NIH HHS R01 HD038665NICHD NIH HHS R01 HD094954NICHD NIH HHS R03 HD096189NICHD NIH HHS R21 HD079908NIH HHS K12 HD065257NIH HHS R01 HD038665NIH HHS R01 HD044406NIH HHS R03 HD096189NIH HHS R21 HD079908
6 · The paper itself

Abstract

introduction and hypothesisTo identify preoperative level II/III MRI measures associated with long-term recurrence after native tissue prolapse repair.

methodsWomen who previously participated in pelvic floor research involving MRI prior to undergoing primary native tissue prolapse repair were recruited to return for repeat examination and MRI. Recurrence was defined by POP-Q (Ba/Bp > 0 or C > -4), repeat surgery, or pessary use. Preoperative MR images were used to perform five level II/III measurements including a new levator plate (LP) shape analysis at rest and maximal Valsalva. Principal component analysis (PCA) was used to evaluate LP shape variations. Principal component scores calculated for two independent shape variations were noted.

resultsThirty-five women were included with a mean follow-up of 13.2 ± 3.3 years. Nineteen (54%) were in the success group. There were no statistical differences between success versus recurrence groups in demographic, clinical, or surgical characteristics. Women with recurrence had a larger preoperative resting levator hiatus [median 6.4 cm (IQR 5.7, 7.1) vs. 5.8 cm (IQR 5.3, 6.3), p = 0.03]. This measure was associated with increased odds of recurrence (OR 8.2, CI 1.4-48.9, p = 0.02). Using PCA, preoperative LP shape PC1 scores were different between success and recurrence groups (p = 0.02), with a more dorsally oriented LP shape associated with recurrence.

conclusionsLarger preoperative levator hiatus at rest and a more dorsally oriented levator plate shape were associated with prolapse recurrence at long-term follow-up. For every 1 cm increase in preoperative resting levator hiatus, the odds of long-term prolapse recurrence increases 8-fold.

Indexed as

Pelvic Organ ProlapseFemaleHumansMagnetic Resonance ImagingPelvic FloorValsalva ManeuverHiatusMRIProlapse recurrenceProlapse surgerySurgical outcomes

Identifiers

PMID34043048
PMCPMC8626527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.