Evidence map›Paper›PMID 34043026›Full record

ArticleCurrent microbiology2021

Anti-Inflammatory Effects of an Extract from Pseudomonas aeruginosa and Its Purified Product 1-Hydroxyphenazine on RAW264.7 Cells.

Jun Xiao, Aye Aye Thwe, Tingting Liu, Dafei Gong, Wanhua Lin, Changhua Shang, ZuJun Lu

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Frontiers in immunology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jun XiaoCollege of Life Science, Guangxi Normal University, No. 1, Yanzhong Road, Yanshan District, Guilin, 541006, Guangxi, China.
Aye Aye ThweCollege of Life Science, Guangxi Normal University, No. 1, Yanzhong Road, Yanshan District, Guilin, 541006, Guangxi, China.
Tingting LiuCollege of Life Science, Guangxi Normal University, No. 1, Yanzhong Road, Yanshan District, Guilin, 541006, Guangxi, China.
Dafei GongCollege of Life Science, Guangxi Normal University, No. 1, Yanzhong Road, Yanshan District, Guilin, 541006, Guangxi, China.
Wanhua LinCollege of Life Science, Guangxi Normal University, No. 1, Yanzhong Road, Yanshan District, Guilin, 541006, Guangxi, China.
Changhua ShangCollege of Life Science, Guangxi Normal University, No. 1, Yanzhong Road, Yanshan District, Guilin, 541006, Guangxi, China. shangchanghua@mailbox.gxnu.edu.cn.ORCID http://orcid.org/0000-0003-1447-6117
ZuJun LuCollege of Life Science, Guangxi Normal University, No. 1, Yanzhong Road, Yanshan District, Guilin, 541006, Guangxi, China. 1946208364@qq.com.ORCID http://orcid.org/0000-0002-2402-2605
Guangxi Normal University · CN

Funding

National Natural Science Foundation of China 31860010Natural Science Foundation of Guangxi Zhuang Autonomous Region 2017JJA130300yNatural Science Foundation of Guangxi Zhuang Autonomous Region 2018GXNSFAA138008Science and Technology Program of Guangzhou, China 201804010155
6 · The paper itself

Abstract

The purpose of this study was to discuss the effects of an extract from the culture medium of Pseudomonas aeruginosa (P. aeruginosa) 2016NX1 (chloroform extract of P. aeruginosa, CEPA) and its purified product 1-hydroxyphenazine on RAW264.7 cell inflammation. Cell viability was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method. TNF-α production was determined by an ELISA method. The effects of CEPA and its purified product 1-hydroxyphenazine on cell morphology were investigated using an inverted microscope. Quantitative real-time PCR was performed to determine mRNA expression levels. CEPA and 1-hydroxyphenazine had no obvious toxicity to cells when their concentrations were no more than 20 μg ml

Indexed as

Anti-Inflammatory AgentsPseudomonas aeruginosaAnimalsInflammationMiceNF-kappa BPhenazinesPlant ExtractsRAW 264.7 Cells1-hydroxyphenazineAnti-Inflammatory AgentsNF-kappa BPhenazinesPlant Extracts

Identifiers

PMID34043026
OpenAlexW3165722838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.