Evidence map›Paper›PMID 34042467›Full record

ArticlemSystems2021

Component Parts of Bacteriophage Virions Accurately Defined by a Machine-Learning Approach Built on Evolutionary Features.

Tze Y Thung, Murray E White, Wei Dai, Jonathan J Wilksch, Rebecca S Bamert, Andrea Rocker, Christopher J Stubenrauch, Daniel Williams, Cheng Huang, Ralf Schittelhelm and 7 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. mBio · 2026
    Article
  4. Article
  5. Phage therapy againstFrontiers in microbiology · 2026
    Review
  6. Article
  7. CombattingAntibiotics (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Optimizing phage therapy with artificial intelligence: a perspective.Frontiers in cellular and infection microbiology · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Tze Y Thung *Infection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Murray E White *Infection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Wei Dai *Infection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Jonathan J WilkschInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Rebecca S BamertInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Andrea RockerInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Christopher J StubenrauchInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Daniel WilliamsInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Cheng HuangMonash Proteomics & Metabolomics Facility, Monash University, Clayton, Australia.
Ralf SchittelhelmMonash Proteomics & Metabolomics Facility, Monash University, Clayton, Australia.
Jeremy J BarrCentre to Impact AMR, Monash University, Clayton, Australia.
Eleanor JamesonSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.
Sheena McGowanInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Yanju ZhangSchool of Computer Science and Information Security, Guilin University of Electronic Technology, Guilin, China.
Jiawei WangInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Rhys A DunstanInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Trevor LithgowInfection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Australian Regenerative Medicine Institute · AUGuilin University of Electronic Technology · CNMonash University · AUUniversity of Warwick · GB

Funding

Australian Research Council FL130100038Monash-Warwick Alliance
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) continues to evolve as a major threat to human health, and new strategies are required for the treatment of AMR infections. Bacteriophages (phages) that kill bacterial pathogens are being identified for use in phage therapies, with the intention to apply these bactericidal viruses directly into the infection sites in bespoke phage cocktails. Despite the great unsampled phage diversity for this purpose, an issue hampering the roll out of phage therapy is the poor quality annotation of many of the phage genomes, particularly for those from infrequently sampled environmental sources. We developed a computational tool called STEP

Indexed as

antimicrobial resistanceartificial intelligencebacteriophagebacteriophagesbacteriophage therapyKlebsiellamachine learningphage therapyvirion structure

Identifiers

PMID34042467
PMCPMC8269216
OpenAlexW3165017612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.