Evidence map›Paper›PMID 34042295›Full record

ArticlePhysiological reports2021

A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo.

Rita Civil, Matthew S Brook, Kirsty J Elliott-Sale, Lívia Santos, Ian Varley, Sanna Lensu, Heikki Kainulainen, Lauren G Koch, Steven L Britton, Daniel J Wilkinson and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Rita CivilMusculoskeletal Physiology Research Group, Sport Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Matthew S BrookClinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Kirsty J Elliott-SaleMusculoskeletal Physiology Research Group, Sport Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Lívia SantosMusculoskeletal Physiology Research Group, Sport Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Ian VarleyMusculoskeletal Physiology Research Group, Sport Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Sanna LensuDepartment of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.ORCID 0000-0001-8197-7590
Heikki KainulainenDepartment of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
Lauren G KochDepartment of Physiology and Pharmacology, The University of Toledo, Toledo, OH, USA.ORCID 0000-0002-2019-5939
Steven L BrittonDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Daniel J WilkinsonClinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Kenneth SmithClinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Craig SaleMusculoskeletal Physiology Research Group, Sport Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Philip J AthertonClinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.ORCID 0000-0002-7286-046X
Nottingham Trent University · GBUniversity of Nottingham · GBUniversity of Jyväskylä · FIUniversity of Michigan · USUniversity of Toledo · US

Funding

Resource for Rat Genetic Models of Aerobic CapacityP40OD021331 · OD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KOCH, LAUREN GERARD · 2015 to 2019
$1.9M
Department of HealthMedical Research Council MR/P021220/1NIH HHS P40 OD021331
6 · The paper itself

Abstract

The development of safe and practical strategies to prevent weakening of bone tissue is vital, yet attempts to achieve this have been hindered by a lack of understanding of the short-term (days-weeks) physiology of bone collagen turnover. To address this, we have developed a method to quantify bone collagen synthesis in vivo, using deuterium oxide (D

Indexed as

AnimalsBone RemodelingCollagenDeuterium OxideFemaleFemurGas Chromatography-Mass SpectrometryMalePyrolysisRadiation-Protective AgentsRatsTibiaCollagenDeuterium OxideRadiation-Protective Agentsbone turnovercollagen synthesisdeuterium oxideGC-pyrolysis-IRMSstable isotopes

Identifiers

PMID34042295
PMCPMC8157767
OpenAlexW3159632850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.