Evidence map›Paper›PMID 34042285›Full record

ArticlePhysiological reports2021

Animal blood in translational research: How to adjust animal blood viscosity to the human standard.

Paul Ecker, Andreas Sparer, Benjamin Lukitsch, Martin Elenkov, Monika Seltenhammer, Richard Crevenna, Margit Gföhler, Michael Harasek, Ursula Windberger

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Paul EckerInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Andreas SparerDecentralized Biomedical Facilities, Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.
Benjamin LukitschInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Martin ElenkovInstitute of Engineering Design and Product Development, TU Wien, Vienna, Austria.
Monika SeltenhammerCenter for Forensic Medicine, Medical University Vienna, Vienna, Austria.
Richard CrevennaUniversity Clinic of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University Vienna, Vienna, Austria.
Margit GföhlerInstitute of Engineering Design and Product Development, TU Wien, Vienna, Austria.
Michael HarasekInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.
Ursula WindbergerDecentralized Biomedical Facilities, Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-5800-9089
TU Wien · ATMedical University of Vienna · ATUniversity Clinic of Traumatology · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animal blood is used in mock circulations or in forensic bloodstain pattern analysis. Blood viscosity is important in these settings as it determines the driving pressure through biomedical devices and the shape of the bloodstain. However, animal blood can never exactly mimic human blood due to erythrocyte properties differing among species. This results in the species-specific shear thinning behavior of blood suspensions, and it is therefore not enough to adjust the hematocrit of an animal blood sample to mimic the behavior of human blood over the entire range of shear rates that are present in the body. In order to optimize experiments that require animal blood, we need models to adapt the blood samples. We here offer mathematical models derived for each species using a multi linear regression approach to describe the influence of shear rate, hematocrit, and temperature on blood viscosity. Results show that pig blood cannot be recommended for experiments at low flow conditions (<200 s

Indexed as

AdultAnimalsBlood ViscosityFemaleHematocritHorsesHumansMaleRheologySheepSpecies SpecificitySwineTranslational Research, BiomedicalYoung Adult

Identifiers

PMID34042285
PMCPMC8157792
OpenAlexW3165347384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.