ArticleJournal of molecular neuroscience : MN2021
Treadmill Exercise Reverses the Change of Dendritic Morphology and Activates BNDF-mTOR Signaling Pathway in the Hippocampus and Cerebral Cortex of Ovariectomized Mice.
Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Sex-specific effects of exercise on motor coordination and extended basal ganglia physiology.bioRxiv : the preprint server for biology · 2026Article
- Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic ERedox biology · 2025Article
- The Effects of the Association Between a High-Fat Diet and Physical Exercise on BDNF Expression in the Hippocampus: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Gut-Bone Axis Mediates Exercise Modality-Dependent Suppression of Inflammatory Osteoclastogenesis in Ovariectomy-Induced Bone Loss.Mediators of inflammation · 2025Article
- Exercise-induced adaptation of neurons in the vertebrate locomotor system.Journal of sport and health science · 2024Review
- Effects and neural mechanisms of different physical activity on major depressive disorder based on cerebral multimodality monitoring: a narrative review.Frontiers in human neuroscience · 2024Review
- Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle.Frontiers in endocrinology · 2024Article
- Deciphering the Influence of Estradiol and Estrogen Receptors on Cognitive Function: A Bibliometric Analysis and Emerging Research Trends.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Executive Function Improvement for Children with Autism Spectrum Disorder: A Comparative Study between Virtual Training and Physical Exercise Methods.Children (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A decline of estrogen level leads to spatial learning and memory impairments, which mediated by hippocampus and cortex. Accumulating evidences demonstrated that aerobic exercise improved memory of postmenopausal women and ovariectomized (OVX) mice. However, the molecular mechanisms for this protection of exercise are not completely clear. Accordingly, the present study was designed to examine the effect of aerobic exercise on the dendritic morphology in the hippocampus and cerebral cortex, as well as the BNDF-mTOR signaling pathway of OVX mice. Adult female C57BL/6 mice were divided into four groups (n = 10/group): sham-operated (SHAM/CON), sham-operated with 8-week treadmill exercise (SHAM/EX), ovariectomized operated (OVX/CON), and ovariectomized operated with exercise (OVX/EX). Aerobic exercise improved the impairment of dendritic morphology significantly induced by OVX that was tested by Golgi staining, and it also upregulated the synaptic plasticity-related protein expression of PSD95 and GluR1 as well as activated BDNF-mTOR signaling pathway in the hippocampus and cerebral cortex. In conclusion, aerobic exercise reversed the change of dendritic morphology and increased the synaptic plasticity-related protein expression in the hippocampus and cerebral cortex of OVX mice. The positive effects induced by exercise might be mediated through the BDNF-mTOR signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.