Evidence map›Paper›PMID 34041673›Full record

ReviewHuman cell2021

The role of long non-coding RNA BCAR4 in human cancers.

Qiong Yi, Zhongcheng Liu, Kun Zhang, Xuening Liu, Lifu Wang, Bin Geng, Yayi Xia

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Epigenetic Abnormalities in Chondrosarcoma.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qiong Yi *Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China.
Zhongcheng Liu *Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China.
Kun ZhangDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China.
Xuening LiuDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China.
Lifu WangDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China.
Bin GengDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China.
Yayi XiaDepartment of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China. xiayylzu@126.com.ORCID http://orcid.org/0000-0002-6758-4130
Gansu Provincial Hospital · CN

Funding

Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital CY2017-QN12Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital CY2017-ZD02National Natural Science Foundation of China 81874017National Natural Science Foundation of China 81960403National Natural Science Foundation of China 82060405National Natural Science Foundation of China 82060413Natrual Science Foundation of Gansu Province of China 20JR5RA320
6 · The paper itself

Abstract

Long non-coding RNA (lncRNA) is a type of non-coding RNA with length of nucleotides > 200 bp. Increasing evidences show that lncRNA breast cancer antiestrogen resistance 4 (BCAR4) plays an important role in the occurrence and development of various human cancers. It is found that BCAR4 is highly expressed in diverse tumor tissues and cells, and the high expression of BCAR4 is usually associated with poor prognosis. BCAR4 is considered as an oncogene in human cancers. By competing endogenous RNA (ceRNA) mechanism and regulating different signaling pathways, BCAR4 participates in the proliferation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), metastasis and tumorigenesis of different cancers. In addition, overexpression of BCAR4 promotes drug resistance of tumor cells. Therefore, BCAR4 is a promising biomarker for cancer diagnosis and prognosis, and it is a potential target for cancer therapy. This paper reviews studies focusing on the relationship between BCAR4 and cancers in recent years and aims to summarize the effect and mechanism of BCAR4 in human cancers.

Indexed as

ApoptosisBiomarkers, TumorCarcinogenesisCell MovementCell ProliferationDrug Resistance, NeoplasmEpithelial-Mesenchymal TransitionGene ExpressionHumansNeoplasm InvasivenessNeoplasm MetastasisNeoplasmsPrognosisRNA, Long NoncodingBCAR4 non-coding RNA, humanBiomarkers, TumorRNA, Long NoncodingBCAR4BiomarkerCancerlncRNAMechanism

Identifiers

PMID34041673
OpenAlexW3164735382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.