Evidence map›Paper›PMID 34041660›Full record

ArticlePituitary2021

Acute elevation of interleukin 6 and matrix metalloproteinase 9 during the onset of pituitary apoplexy in Cushing's disease.

Takako Araki, Jutarat Sangtian, Darin Ruanpeng, Ramachandra Tummala, Brent Clark, Lynn Burmeister, Daniel Peterson, Andrew S Venteicher, Yasuhiko Kawakami

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pituitary, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Takako ArakiDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA. taraki@umn.edu.ORCID http://orcid.org/0000-0002-4451-1668
Jutarat SangtianDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA.
Darin RuanpengDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA.
Ramachandra TummalaDepartment of Neurosurgery, University of Minnesota, 500 SE Harvard St., Minneapolis, MN, 55455, USA.
Brent ClarkDepartment of Laboratory Medicine and Pathology, University of Minnesota, 500 SE Harvard St., Minneapolis, MN, 55455, USA.
Lynn BurmeisterDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA.
Daniel PetersonSpecial Chemistry Laboratory, University of Minnesota Fairview Clinic, 500 SE Harvard St., Minneapolis, MN, 55455, USA.
Andrew S VenteicherDepartment of Neurosurgery, University of Minnesota, 500 SE Harvard St., Minneapolis, MN, 55455, USA.
Yasuhiko KawakamiDepartment of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St. SE., 6-160 Jackson Hall, Minneapolis, MN, 55455, USA.
University of Minnesota · US

Funding

Genetic Regulation of Progenitor Cells in Appendicular Skeletal DevelopmentR01AR064195 · NIAMS · UNIVERSITY OF MINNESOTA · PI KAWAKAMI, YASUHIKO · 2013 to 2022
$3.3M
Graduate School, University of Minnesota AHC Grant-in-Aid 212588Graduate School, University of Minnesota UMF0011528National Institute of Child Health and Human Development R01AR064195NIAMS NIH HHS R01 AR064195
6 · The paper itself

Abstract

purposePituitary apoplexy is a rare endocrine emergency. The purpose of this study is to characterize physiological changes involved in pituitary apoplexy, especially during the acute phase.

methodsA Cushing's disease patient experienced corticotroph releasing hormone (CRH)-induced pituitary apoplexy during inferior petrosal sinus sampling (IPSS). The IPSS blood samples from the Cushing's disease patient were retrospectively analyzed for cytokine markers. For comparison, we also analyzed cytokine markers in blood samples from two pituitary ACTH-secreting microadenoma patients and one patient with an ectopic ACTH-secreting tumor.

resultsAcute elevation of interleukin 6 (IL-6) and matrix metalloproteinase 9 (MMP9) was observed in the IPSS blood sample on the apoplectic hemorrhagic site of the tumor. In contrast, such a change was not observed in the blood samples from the contralateral side of the apoplexy patient and in other IPSS samples from two non-apoplexy Cushing's disease patient and a patient with ectopic Cushing's syndrome.

conclusionIL-6 and MMP9 may be involved in the acute process of pituitary apoplexy in Cushing's disease.

Indexed as

AdenomaInterleukin-6Matrix Metalloproteinase 9Pituitary ACTH HypersecretionPituitary ApoplexyPituitary NeoplasmsCorticotropin-Releasing HormoneHumansPetrosal Sinus SamplingRetrospective StudiesCorticotropin-Releasing HormoneIL6 protein, humanInterleukin-6Matrix Metalloproteinase 9MMP9 protein, humanCRHCushing's diseaseIL-6MMP9Pituitary apoplexy

Identifiers

PMID34041660
PMCPMC8551006
OpenAlexW3165071922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.