Evidence map›Paper›PMID 34041623›Full record

ArticleNeurochemical research2021

Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome.

Jing Li, Maxim Nelis, Jo Sourbron, Daniëlle Copmans, Lieven Lagae, Deirdre Cabooter, Peter A M de Witte

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Nontraditional Antiseizure Medications to Consider When Traditional Options Have Failed: Medications for Refractory Seizures and Epilepsies.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Sigma-1 receptor and seizures.Pharmacological research · 2023
    Review
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jing LiDepartment of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, University of Leuven (KU Leuven), Herestraat 49, 824, 3000, Leuven, Belgium.
Maxim NelisDepartment of Pharmaceutical and Pharmacological Sciences, Laboratory for Pharmaceutical Analysis, University of Leuven (KU Leuven), Leuven, Belgium.
Jo SourbronDepartment of Pediatric Neurology, University Hospitals Leuven, Leuven, Belgium.
Daniëlle CopmansDepartment of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, University of Leuven (KU Leuven), Herestraat 49, 824, 3000, Leuven, Belgium.
Lieven LagaeDepartment of Pediatric Neurology, University Hospitals Leuven, Leuven, Belgium.
Deirdre CabooterDepartment of Pharmaceutical and Pharmacological Sciences, Laboratory for Pharmaceutical Analysis, University of Leuven (KU Leuven), Leuven, Belgium.
Peter A M de WitteDepartment of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, University of Leuven (KU Leuven), Herestraat 49, 824, 3000, Leuven, Belgium. peter.dewitte@kuleuven.be.ORCID http://orcid.org/0000-0002-9989-9567
KU Leuven · BE

Funding

Chinese Scholarship Council doctoral fellowship 201606250020
6 · The paper itself

Abstract

Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic drugs (AEDs). In 2020, FDA has approved fenfluramine (FFA) for treatment of seizures associated with DS. However, the clinically used FFA is a racemic mixture (i.e. (±)-FFA), that is substantially metabolized to norfenfluramine (norFFA), and it is presently not known whether the efficacy of FFA is due to a single enantiomer of FFA, or to both, and whether the norFFA enantiomers also contribute significantly. In this study, the antiepileptic activity of enantiomers of FFA (i.e. (+)-FFA and (-)-FFA) and norFFA (i.e. (+)-norFFA and (-)-norFFA) was explored using the zebrafish scn1Lab

Indexed as

AnimalsAnticonvulsantsEpilepsies, MyoclonicFenfluramineHeadNorfenfluramineStereoisomerismZebrafishAnticonvulsantsFenfluramineNorfenfluramineAntiepileptic activityDravet syndromeEnantiomersFenfluramineNorfenfluramineZebrafish

Identifiers

PMID34041623
PMCPMC8302504
OpenAlexW3164066679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.