Evidence map›Paper›PMID 34041534›Full record

ArticleJournal of biomechanical engineering2021

An In Vitro Study to Investigate Biomechanical Responses of Peripheral Nerves in Hypoxic Neonatal Piglets.

Anita Singh, Rachel Magee, Sriram Balasubramanian

Abstract read
In one paragraph

Article in Journal of biomechanical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anita SinghBiomedical Engineering, School of Engineering, Widener University, Chester, PA 19013.
Rachel MageeSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104.
Sriram BalasubramanianSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104.

Funding

Biomechanical and Functional Injury Thresholds and Related Histological Changes in Neonatal Brachial PlexusR15HD093024 · NICHD · WIDENER UNIVERSITY · PI SINGH, ANITA · 2017 to 2017
$417k
NICHD NIH HHS R15 HD093024NICHD NIH HHS R15HD093024
6 · The paper itself

Abstract

Despite occurrence of neonatal hypoxia and peripheral nerve injuries in complicated birthing scenarios, the effect of hypoxia on the biomechanical responses of neonatal peripheral nerves is not studied. In this study, neonatal brachial plexus (BP) and tibial nerves, obtained from eight normal and eight hypoxic 3-5-day-old piglets, were tested in uniaxial tension until failure at a rate of 0.01 mm/s or 10 mm/s. Failure load, stress, and modulus of elasticity were reported to be significantly lower in hypoxic neonatal BP and tibial nerves than respective normal tissue at both 0.01 and 10 mm/s rates. Failure strain was significantly lower in the hypoxic neonatal BP nerves only at 10 mm/s rate when compared to normal BP nerve. This is the first available data that indicate weaker mechanical behavior of hypoxic neonatal peripheral nerves as compared to normal tissue and offer an understanding of the biomechanical responses of peripheral nerves of hypoxic neonatal piglets.

Indexed as

Animals, NewbornHypoxiaAnimalsBiomechanical PhenomenaBrachial PlexusElastic ModulusMechanical PhenomenaPeripheral NervesStress, MechanicalSwineTibial Nervebrachial plexushypoxiainjuryneonatalstretch

Identifiers

PMID34041534
PMCPMC8299807

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.