Evidence map›Paper›PMID 34041495›Full record

ArticleNeurobiology of language (Cambridge, Mass.)2020

Linking Lysosomal Enzyme Targeting Genes and Energy Metabolism with Altered Gray Matter Volume in Children with Persistent Stuttering.

Ho Ming Chow, Emily O Garnett, Hua Li, Andrew Etchell, Jorge Sepulcre, Dennis Drayna, Diane Chugani, Soo-Eun Chang

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of language (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. An active inference account of stuttering behavior.Frontiers in human neuroscience · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Stuttering as a spectrum disorder: A hypothesis.Current research in neurobiology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Stuttering: A Disorder of Energy Supply to Neurons?Frontiers in human neuroscience · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Ho Ming ChowDepartment of Communication Sciences and Disorders, University of Delaware, Newark, DE.
Emily O GarnettDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.ORCID https://orcid.org/0000-0003-1490-9541
Hua LiKatzin Diagnostic & Research PET/MRI Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.
Andrew EtchellDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.
Jorge SepulcreGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Dennis DraynaNational Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD.ORCID https://orcid.org/0000-0002-1730-4532
Diane ChuganiDepartment of Communication Sciences and Disorders, University of Delaware, Newark, DE.
Soo-Eun ChangDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.ORCID https://orcid.org/0000-0003-4448-9525
University of Michigan · USAlfred I. duPont Hospital for Children · USHarvard University · USNational Institute on Deafness and Other Communication Disorders · USUniversity of Delaware · US

Funding

Sexual dimorphism of neural development underlying childhood stutteringR01DC011277 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Soo-Eun Chang · 2010 to 2026
$8.2M
Neural Markers of Persistence and Recovery from Childhood Stuttering: An fMRI Study of Continuous Speech ProductionR21DC015853 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOW, HO MING · 2016 to 2018
$454k
Imaging genetics study of twins who stutterR21DC015312 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHANG, SOO-EUN · 2017 to 2018
$440k
NIDCD NIH HHS R01 DC011277NIDCD NIH HHS R21 DC015312NIDCD NIH HHS R21 DC015853
6 · The paper itself

Abstract

Developmental stuttering is a childhood onset neurodevelopmental disorder with an unclear etiology. Subtle changes in brain structure and function are present in both children and adults who stutter. It is a highly heritable disorder, and 12-20% of stuttering cases may carry a mutation in one of four genes involved in intracellular trafficking. To better understand the relationship between genetics and neuroanatomical changes, we used gene expression data from the Allen Institute for Brain Science and voxel-based morphometry to investigate the spatial correspondence between gene expression patterns and differences in gray matter volume between children with persistent stuttering (

Indexed as

longitudinallysosomemetabolismstutteringvoxel-based morphometry

Identifiers

PMID34041495
PMCPMC8138901
OpenAlexW3033802391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.