Evidence map›Paper›PMID 34041487›Full record

ArticleRSC medicinal chemistry2021

Collaborative virtual screening to elaborate an imidazo[1,2-

Yuichiro Akao, Stacie Canan, Yafeng Cao, Kevin Condroski, Ola Engkvist, Sachiko Itono, Rina Kaki, Chiaki Kimura, Thierry Kogej, Kazuya Nagaoka and 14 more

Open access · hybridAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 39 citations in OpenAlex.

  1. Imidazo[1,2‑ACS omega · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Current leishmaniasis drug discovery.RSC medicinal chemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 9 countries.

Yuichiro AkaoTakeda Pharmaceutical Company Limited 26-1 Muraoka-Higashi 2-chrome Fujisawa Kanagawa 251-8555 Japan.
Stacie CananCelgene Corporation, Celgene Global Health 10300 Campus Point Drive San Diego California 92121 USA.
Yafeng CaoWuXi AppTec Company Ltd. 666 Gaoxin Road, East Lake High-Tech Development Zone Wuhan 430075 People's Republic of China.
Kevin CondroskiCelgene Corporation, Celgene Global Health 10300 Campus Point Drive San Diego California 92121 USA.
Ola EngkvistAstraZeneca Discovery Sciences, R&D AstraZeneca Gothenburg Sweden.ORCID https://orcid.org/0000-0003-4970-6461
Sachiko ItonoTakeda Pharmaceutical Company Limited 26-1 Muraoka-Higashi 2-chrome Fujisawa Kanagawa 251-8555 Japan.
Rina KakiShionogi & Co., Ltd 3-1-1, Futaba-cho Toyonaka-shi Osaka Japan.
Chiaki KimuraShionogi & Co., Ltd 3-1-1, Futaba-cho Toyonaka-shi Osaka Japan.
Thierry KogejAstraZeneca Discovery Sciences, R&D AstraZeneca Gothenburg Sweden.
Kazuya NagaokaEisai Co., Ltd 1-3,Tokodai 5-chome Tsukuba Ibaraki 300-2635 Japan.
Akira NaitoShionogi & Co., Ltd 3-1-1, Futaba-cho Toyonaka-shi Osaka Japan.
Hiromi NakaiShionogi & Co., Ltd 3-1-1, Futaba-cho Toyonaka-shi Osaka Japan.
Garry PairaudeauAstraZeneca, Discovery Sciences, R&D AstraZeneca Cambridge UK.
Constantin RaduInstitut Pasteur Korea 16, Daewangpangyo-ro 712 beon-gil, Bundang-gu Seongnam-si Gyeonggi-do 13488 Republic of Korea.
Ieuan RobertsAstraZeneca, Discovery Sciences, R&D AstraZeneca Cambridge UK.
Mitsuyuki ShimadaTakeda Pharmaceutical Company Limited 26-1 Muraoka-Higashi 2-chrome Fujisawa Kanagawa 251-8555 Japan.
David ShumInstitut Pasteur Korea 16, Daewangpangyo-ro 712 beon-gil, Bundang-gu Seongnam-si Gyeonggi-do 13488 Republic of Korea.
Nao-Aki WatanabeEisai Co., Ltd 1-3,Tokodai 5-chome Tsukuba Ibaraki 300-2635 Japan.
Huanxu XieWuXi AppTec Company Ltd. 666 Gaoxin Road, East Lake High-Tech Development Zone Wuhan 430075 People's Republic of China.
Shuji YonezawaShionogi & Co., Ltd 3-1-1, Futaba-cho Toyonaka-shi Osaka Japan.
Osamu YoshidaShionogi & Co., Ltd 3-1-1, Futaba-cho Toyonaka-shi Osaka Japan.
Ryu YoshidaShionogi & Co., Ltd 3-1-1, Futaba-cho Toyonaka-shi Osaka Japan.
Charles MowbrayDrugs for Neglected Diseases initiative 15 Chemin Louis Dunant Geneva 1202 Switzerland bperry@dndi.org.
Benjamin PerryDrugs for Neglected Diseases initiative 15 Chemin Louis Dunant Geneva 1202 Switzerland bperry@dndi.org.ORCID https://orcid.org/0000-0001-6715-4213
Toyonaka Municipal Hospital · JPFujisawa City Hospital · JPAstraZeneca (Singapore) · SGAstraZeneca (United Kingdom) · GBBristol-Myers Squibb (Switzerland) · CHDrugs for Neglected Diseases Initiative · CHEisai (Japan) · JPInstitut Pasteur Korea · KRWuXi AppTec (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-

Identifiers

PMID34041487
PMCPMC8130605
OpenAlexW3108384711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.