Evidence map›Paper›PMID 34041454›Full record

ArticleiScience2021

Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states.

Ravi Jasuja, Daniel Spencer, Abhilash Jayaraj, Liming Peng, Meenakshi Krishna, Brian Lawney, Priyank Patel, Bhyravabhotla Jayaram, Kelly M Thayer, David L Beveridge and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ravi JasujaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Daniel SpencerResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abhilash JayarajSupercomputing Facility for Bioinformatics and Computational Biology, Indian Institute of Technology, New Delhi, 110 016 India.
Liming PengResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Meenakshi KrishnaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brian LawneyCenter for Cancer Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Priyank PatelResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bhyravabhotla JayaramSupercomputing Facility for Bioinformatics and Computational Biology, Indian Institute of Technology, New Delhi, 110 016 India.
Kelly M ThayerDepartments of Chemistry, Molecular Biology, and Biochemistry and Molecular Biophysics Program, Wesleyan University, Middletown, CT, USA.
David L BeveridgeDepartments of Chemistry, Molecular Biology, and Biochemistry and Molecular Biophysics Program, Wesleyan University, Middletown, CT, USA.
Shalender BhasinResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USWesleyan University · USDana-Farber Cancer Institute · USIndian Institute of Technology Delhi · IN

Funding

Ensemble Networks for Allosteric Drug DesignR15GM128102 · NIGMS · WESLEYAN UNIVERSITY · PI THAYER, KELLY MARIE · 2018 to 2021
$976k
An MD-MSM Study of Allosterism on the DNA Repair Protein MutSR15GM129715 · NIGMS · WESLEYAN UNIVERSITY · PI BEVERIDGE, DAVID LEWIS · 2018 to 2018
$488k
Librational Mode Coupling Theory of Allosteric Signal TransmissionR15GM144870 · NIGMS · WESLEYAN UNIVERSITY · PI BEVERIDGE, DAVID LEWIS · 2022 to 2022
$482k
NIGMS NIH HHS R15 GM128102NIGMS NIH HHS R15 GM129715NIGMS NIH HHS R15 GM144870
6 · The paper itself

Abstract

Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer with identical affinity (K

Indexed as

BiochemistryEndocrinology

Identifiers

PMID34041454
PMCPMC8144348
OpenAlexW3153513442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.