ArticleiScience2021
Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling.
Erratum issuedOpen access · goldAbstract read
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Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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22citing papers in PubMed
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22 citing papers in PubMed, 47 citations in OpenAlex.
- Bioactive Components ofAntioxidants (Basel, Switzerland) · 2026Review
- The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease.Biomedicines · 2026Review
- Specific inhibition of NLRP3 inflammasome by a Smurf1 inhibitorOpen medicine (Warsaw, Poland) · 2026Article
- Review
- YAP/TAZ as master regulators in liver regeneration and disease: insights into mechanisms and therapeutic targets.Molecular biology reports · 2024Review
- DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability.Immunologic research · 2024Article
- E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction-Associated Steatohepatitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Adipocyte-specific Nrf2 deletion negates nitro-oleic acid benefits on glucose tolerance in diet-induced obesity.Nitric oxide : biology and chemistry · 2024Article
- Macrophage Perspectives in Liver Diseases: Programmed Death, Related Biomarkers, and Targeted Therapy.Biomolecules · 2024Review
- Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis.Journal of orthopaedic surgery and research · 2023Article
- Quantitative proteomic analyses uncover regulatory roles of Nrf2 in human endothelial cells.Cell stress & chaperones · 2023Article
- Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis.Transplantation direct · 2023Article
- A new NRF2 activator for the treatment of human metabolic dysfunction-associated fatty liver disease.JHEP reports : innovation in hepatology · 2023Article
- Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC.Molecular medicine (Cambridge, Mass.) · 2023Article
- From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria.Biology · 2023Review
- Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice.JHEP reports : innovation in hepatology · 2023Article
- Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis.Frontiers in pharmacology · 2023Review
- Programmed cell death and lipid metabolism of macrophages in NAFLD.Frontiers in immunology · 2023Review
- Role of the Hippo pathway in liver regeneration and repair: recent advances.Inflammation and regeneration · 2022Review
- Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis.Frontiers in immunology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 1 institution in 1 country.
Peng WangHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Ming NiHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Yizhu TianHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Hao WangHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Jiannan QiuHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Wenhua YouHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Song WeiHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Yong ShiHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Jinren ZhouHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Feng ChengHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Jianhua RaoHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Ling LuHepatobiliary Center of The First Affiliated Hospital and The Affiliated Cancer Hospital (Jiangsu Cancer Hospital), School of Biomedical Engineering and Informatics, Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, 300 Guang Zhou Road, Nanjing, China.
Jiangsu Cancer Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear-erythroid-2-related factor 2 (Nrf2) is involved in the pathogenesis of different liver diseases. Herein, we first demonstrated that Nrf2 expression was diminished in nonalcoholic steatohepatitis (NASH) liver macrophages. In myeloid Nrf2-deficiency mice, aggravated liver steatosis and inflammation in high-fat-diet (HFD)-fed mice were observed compared with the chow-diet group. Moreover, the increasing inflammatory cytokines influenced the lipid metabolism in hepatocytes
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Endocrine System PhysiologyHuman MetabolismImmunologyPhysiology
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