Evidence map›Paper›PMID 34041139›Full record

ReviewJournal of family medicine and primary care2021

Hydroxychloroquine: A review of its safety and efficacy in COVID-19.

Rutu H Karia, Sanjana Nagraj, Ishita Gupta, Amit Barua, Nirmaljot Kaur, Harmandeep Singh

Open access · goldAbstract readReview
In one paragraph

Review in Journal of family medicine and primary care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rutu H KariaAnna Medical College and Research Centre, Mauritius.
Sanjana NagrajInternal Medicine, Jacobi Medical Centre/Albert Einstein College of Medicine, New York, USA.
Ishita GuptaDr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.
Amit BaruaInstitute of Applied Health Sciences, Chattogram, Bangladesh.
Nirmaljot KaurSri Guru Ramdas Institute of Medical Sciences and Research, Amritsar, Punjab, India.
Harmandeep SinghSri Guru Ramdas Institute of Medical Sciences and Research, Amritsar, Punjab, India.
Institute of Medical Sciences · INDr. Rajendra Prasad Government Medical College · INUniversity of Science and Technology Chittagong · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 is a novel virus that has infected millions of people across the world. Given the compelling need to develop a therapeutic strategy, hydroxychloroquine has been advocated as an effective drug for the infection. However, multiple clinical trials conducted using hydroxychloroquine have yielded contrasting results. An electronic search using the primary databases from WHO, PubMed and Google Scholar was performed that yielded 21 studies eligible for inclusion. Among a total of 1,350 patients who received hydroxychloroquine, 689 (51.04%) were females. The most commonly reported comorbidities include hypertension (15.18%), diabetes mellitus (8.44%) and pulmonary disease (8.96%). Of the hydroxychloroquine-treated patients, 70% were virologically cured compared to 12.5% of the control group (

Indexed as

Chloroquineefficacyhydroxychloroquinesafetytreatments of COVID-19

Identifiers

PMID34041139
PMCPMC8140271
OpenAlexW3153679424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.