ReviewFrontiers in cellular and infection microbiology2021
Genetic Manipulation of Ticks: A Paradigm Shift in Tick and Tick-Borne Diseases Research.
Review in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Genome-wide CRISPR knockout cell screening platform for the disease vector tick speciesbioRxiv : the preprint server for biology · 2026Article
- Tick genomics through a Nanopore: a low-cost approach for tick genomics.BMC genomics · 2025Article
- The hypusine pathway inFrontiers in cellular and infection microbiology · 2025Article
- Alarming implications: severe fever with thrombocytopenia syndrome and its biological vectors in the context of climate change.Frontiers in microbiology · 2025Review
- Validation of heat-inducibleiScience · 2024Article
- Laboratory Management of Mammalian Hosts forComparative medicine · 2024Review
- Arthropod promoters for genetic control of disease vectors.Trends in parasitology · 2024Review
- Genes drive organisms and slippery slopes.Pathogens and global health · 2024Review
- The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection.Parasites & vectors · 2024Article
- Validation of a heat-induciblebioRxiv : the preprint server for biology · 2023Article
- Rab27 in tick extracellular vesicle biogenesis and infection.bioRxiv : the preprint server for biology · 2023Article
- Tick extracellular vesicles in host skin immunity and pathogen transmission.Trends in parasitology · 2023Review
- RNA activation in ticks.Scientific reports · 2023Article
- Cas9-mediated gene editing in the black-legged tick,iScience · 2022Article
- The environment, the tick, and the pathogen - It is an ensemble.Frontiers in cellular and infection microbiology · 2022Review
- Editorial: Tick Saliva: Secret to Blood Feeding Success.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ticks are obligate hematophagous arthropods that are distributed worldwide and are one of the most important vectors of pathogens affecting humans and animals. Despite the growing burden of tick-borne diseases, research on ticks has lagged behind other arthropod vectors, such as mosquitoes. This is largely because of challenges in applying functional genomics and genetic tools to the idiosyncrasies unique to tick biology, particularly techniques for stable genetic transformations. CRISPR-Cas9 is transforming non-model organism research; however, successful germline editing has yet to be accomplished in ticks. Here, we review the ancillary methods needed for transgenic tick development and the use of CRISPR/Cas9, the most promising gene-editing approach, for tick genetic transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.