Evidence map›Paper›PMID 34041025›Full record

ReviewFrontiers in oncology2021

Immunotherapy in Acute Myeloid Leukemia: Where We Stand.

Alessandro Isidori, Claudio Cerchione, Naval Daver, Courtney DiNardo, Guillermo Garcia-Manero, Marina Konopleva, Elias Jabbour, Farhad Ravandi, Tapan Kadia, Adolfo de la Fuente Burguera and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  11. Frontiers in oncology · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Alessandro IsidoriHaematology and Stem Cell Transplant Center, AORMN, Pesaro, Italy.
Claudio CerchioneHematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
Naval DaverDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Courtney DiNardoDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Guillermo Garcia-ManeroDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Marina KonoplevaDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Elias JabbourDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Farhad RavandiDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Tapan KadiaDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Adolfo de la Fuente BurgueraMD Anderson Cancer Center, Madrid, Spain.
Alessandra RomanoDipartimento di Chirurgia e Specialità Medico-Chirurgiche, Sezione di Ematologia, Università degli Studi di Catania, Catania, Italy.
Federica LoscoccoHaematology and Stem Cell Transplant Center, AORMN, Pesaro, Italy.
Giuseppe VisaniHaematology and Stem Cell Transplant Center, AORMN, Pesaro, Italy.
Giovanni MartinelliHematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
Hagop KantarjianHematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
Antonio CurtiIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
The University of Texas MD Anderson Cancer Center · USIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto di Ematologia di Bologna · ITMD Anderson Cancer Center Madrid · ESUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past few years, our improved knowledge of acute myeloid leukemia (AML) pathogenesis has led to the accelerated discovery of new drugs and the development of innovative therapeutic approaches. The role of the immune system in AML development, growth and recurrence has gained increasing interest. A better understanding of immunological escape and systemic tolerance induced by AML blasts has been achieved. The extraordinary successes of immune therapies that harness the power of T cells in solid tumors and certain hematological malignancies have provided new

Indexed as

acute myeloid leukemiacheckpoint inhibitorsimmunotherapymonoclonal antibodynatural killertolerance

Identifiers

PMID34041025
PMCPMC8143531
OpenAlexW3163829944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.