ArticleChemical science2021
Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Exploring the Potential of Site-Selective Labeling on a Green Fluorescent Protein Through Lys-His Linchpin-Directed Modification.Sensors (Basel, Switzerland) · 2026Article
- Recent advances in site-specific modifications of peptides and proteins.Chemical science · 2026Review
- Site-specific labelling of native peptides and proteins: chemical and enzymatic strategies.Beilstein journal of organic chemistry · 2026Review
- Site-Specific Histidine Aza-Michael Addition in Proteins Enabled by a Ferritin-Based Metalloenzyme.Journal of the American Chemical Society · 2024Article
- Review
- Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry.Journal of the American Chemical Society · 2023Article
- Traceless cysteine-linchpin enables precision engineering of lysine in native proteins.Nature communications · 2022Article
- Chemical Conjugation to Less Targeted Proteinogenic Amino Acids.Chembiochem : a European journal of chemical biology · 2022Review
- Calibrating Catalytic DNA Nanostructures for Site-Selective Protein Modification.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- An overview of chemo- and site-selectivity aspects in the chemical conjugation of proteins.Royal Society open science · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to enable site-selectivity for histidine and aspartic acid modifications overcoming the pre-requisite of chemoselectivity.
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Registered trials
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