ArticleChemical science2021
Radical-based functionalization-oriented construction: rapid assembly of azaarene-substituted highly functionalized pyrroles.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dicyanopyrazine: 10th Anniversary in Photoredox Catalysis.Chemical record (New York, N.Y.) · 2025Article
- Construction of pyrroles, furans and thiophenesChemical science · 2023Article
- Synthesis of unsymmetrically tetrasubstituted pyrroles and studies of AIEE in pyrrolo[1,2-Chemical science · 2022Article
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Authors and funding
5 authors.
Funding
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Abstract
Totally different functionalization and construction as two fundamental synthetic protocols have long been applied to furnish azaarene variants. Here, a novel radical-based functionalization-oriented construction strategy by exploiting the electronic properties of azaarenes and the high reactivity of radicals is developed. Under a photoredox catalysis platform, the robust ability of such an artful combination of functionalization with construction is disclosed in the synthesis of valuable 3-azaarene-substituted densely functionalized pyrroles. In addition to the ability to use the readily accessible feedstocks, the high synthetic efficiency and the good functional group tolerance, the substrate scope is broad (81 examples) resulting from the capability to flexibly replace the types of azaarenes and other substituents. Control experiments and density functional theory (DFT) calculations elucidate the plausible mechanism involving the reaction pathways and the important role of NaH
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