Evidence map›Paper›PMID 34040716›Full record

ArticleChemical science2019

Probing the mechanism for hydrogel-based stasis induction in human pluripotent stem cells: is the chemical functionality of the hydrogel important?

M Sponchioni, C T O'Brien, C Borchers, E Wang, M N Rivolta, N J W Penfold, I Canton, S P Armes

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Thermoresponsive Poly(Biomacromolecules · 2023
    Article
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  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

M SponchioniDepartment of Chemistry, University of Sheffield Dainton Building Sheffield S3 7HF UK s.p.armes@sheffield.ac.uk.ORCID https://orcid.org/0000-0002-8130-6495
C T O'BrienDepartment of Chemistry, University of Sheffield Dainton Building Sheffield S3 7HF UK s.p.armes@sheffield.ac.uk.
C BorchersDepartment of Chemistry, University of Sheffield Dainton Building Sheffield S3 7HF UK s.p.armes@sheffield.ac.uk.
E WangDepartment of Biochemistry and Molecular Genetics, University of Louisville Louisville Kentucky 40202 USA.
M N RivoltaDepartment of Biomedical Science, University of Sheffield Western Bank Sheffield S10 2TN UK.ORCID https://orcid.org/0000-0003-4178-8570
N J W PenfoldDepartment of Chemistry, University of Sheffield Dainton Building Sheffield S3 7HF UK s.p.armes@sheffield.ac.uk.ORCID https://orcid.org/0000-0002-6505-3782
I CantonDepartment of Chemistry, University of Sheffield Dainton Building Sheffield S3 7HF UK s.p.armes@sheffield.ac.uk.
S P ArmesDepartment of Chemistry, University of Sheffield Dainton Building Sheffield S3 7HF UK s.p.armes@sheffield.ac.uk.ORCID https://orcid.org/0000-0002-8289-6351
University of Sheffield · GBUniversity of Louisville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well-known that pluripotent human embryonic stem cells (hPSC) can differentiate into any cell type. Recently, we reported that hPSC colonies enter stasis when immersed in an extremely soft hydrogel comprising hydroxyl-functional block copolymer worms (I. Canton, N. J. Warren, A. Chahal, K. Amps, A. Wood, R. Weightman, E. Wang, H. Moore and S. P. Armes,

Identifiers

PMID34040716
PMCPMC8133024
OpenAlexW2988608495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.