ArticleInternational journal of dentistry2021
Phosphate Ion Release and Alkalizing Potential of Three Bioactive Dental Materials in Comparison with Composite Resin.
Article in International journal of dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Bioactive inorganic materials in dental resin infiltrants: a systematic and critical review of their effects on infiltrant properties and tooth surfaces.Clinical oral investigations · 2025Pooled it
- Clinical performance of an alkasite-based bioactive restorative in class II cavities: a randomized clinical trial.Journal of applied oral science : revista FOB · 2023Trial
- Comparison of novel bioactive nanosilver-reinforced sealant with three bioactive materials as pit and fissure sealants: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Biological and Mechanical Comparison of Eggshell-Derived Hydroxyapatite, Calcium Hydroxide, and Mineral Trioxide Aggregate.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- The Clinical Performance of Activa Bioactive Composite Compared to Composite in Restoring Class II Cavities in Primary Teeth: 1 Year of Split-Mouth Randomized Clinical Trial.European journal of dentistry · 2026Article
- Comparison of Mechanical and Surface Properties of Glass Ionomer, Resin-modified Glass Ionomer, and Alkasite Restorative Materials.International journal of clinical pediatric dentistry · 2026Article
- Bioactive Fillers in Bulk-Fill Composite Resins: A Comprehensive Review of the Effects on Polymerization Shrinkage Behavior and Mechanical Performance.Materials (Basel, Switzerland) · 2026Review
- Repair Bond Strength of Ion-Releasing Versus Conventional Resin Composites.Materials (Basel, Switzerland) · 2026Article
- Cytotoxicity and bonding property of biomimetic ceramic fiber-resin composites.BMC oral health · 2026Article
- Elemental and micromorphological analysis of ion releasing restoration/carious dentin interface.Scientific reports · 2025Article
- The effect of ozone application on the color stability and surface roughness of restorative materials aged with different solutions: an in vitro study.BMC oral health · 2025Article
- Ion release dynamics of bioactive resin cement under variable pH conditions.Frontiers in oral health · 2025Article
- Comparative evaluation of surface roughness and bacterial adhesion on two bioactive cements: an in-vitro study.BMC oral health · 2024Article
- Elemental analysis and micromorphological patterns of tooth/restoration interface of three ion-releasing class V restorations.BMC oral health · 2024Article
- Effect of polymerization mode on shrinkage kinetics and degree of conversion of dual-curing bulk-fill resin composites.Clinical oral investigations · 2023Article
- Assessment of remineralisation potentials of bioactive dental composite using an in-vitro demineralised dentine model.Journal of Taibah University Medical Sciences · 2022Article
- Marginal microleakage and modified microtensile bond strength of Activa Bioactive, in comparison with conventional restorative materials.Clinical and experimental dental research · 2022Article
- Long-term ion release, fluoride recharge, pH modulation, and mechanical aging of an experimental ACP-based composite compared with contemporary bioactive restorative materials.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSeveral new bioactive compounds were recently introduced to the market with favorable ion release, tooth remineralization, and alkalizing potential. This study sought to compare the phosphate ion release and alkalizing potential of three bioactive materials in comparison with composite resin.
methodsThirty-six discs (2 × 6 mm) were fabricated from Fuji II LC resin modified glass ionomer (RMGI), Activa BioActive, Cention N, and Z250 composite in plastic molds. The specimens were stored in distilled water for 24 and 48 h and 6 months. Half of the specimens were used to assess the phosphate ion release while the other half were used to assess the alkalizing potential 1 h after pH drop from 6.8 to 4. Phosphate ion release was quantified by a spectrophotometer while the pH value was measured by a pH meter. Data were analyzed using two-way ANOVA, one-way ANOVA, and Tukey's HSD test (for pairwise comparisons) at 0.05 level of significance.
resultsAt 24 h, the maximum phosphate ion release in distilled water occurred in the Fuji II LC group followed by Cention N, Activa BioActive, and Z250. At 6 months, Cention N followed by Activa BioActive showed higher phosphate ion release than Fuji II LC and Z250. No significant difference was noted between Activa BioActive and Cention N at any time point. All materials, except for Z250, increased the pH of the environment. Fuji II LC had maximum alkalizing effect at all time points followed by Cention N and Activa BioActive.
conclusionUse of bioactive compounds is a promising method to ensure phosphate ion release, and can have a positive effect on tooth remineralization over time. Also, bioactive compounds can alkalize an acidic environment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.