Evidence map›Paper›PMID 34040617›Full record

ArticleFrontiers in immunology2021

Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel

Thomas Mika, Deepak Vangala, Matthias Eckhardt, Paul La Rosée, Christoph Lange, Kai Lehmberg, Charlotte Wohlschläger, Saskia Biskup, Ilka Fuchs, Jasmin Mann and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Thomas MikaDepartment of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
Deepak VangalaDepartment of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
Matthias EckhardtDepartment of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
Paul La RoséeKlinik für Innere Medizin II, Schwarzwald-Baar-Klinikum, Villingen-Schwenningen, Germany.
Christoph LangeMedical Clinic, Research Center Borstel, Borstel, Germany.
Kai LehmbergClinic for Pediatric Hematology, University Medical Center Eppendorf, Hamburg, Germany.
Charlotte WohlschlägerHematopathology Lübeck, Lübeck, Germany.
Saskia BiskupCeGaT and Practice for Human Genetics, Tübingen, Germany.
Ilka FuchsInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg i.Br., Germany.
Jasmin MannInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg i.Br., Germany.
Stephan EhlInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg i.Br., Germany.
Klaus WarnatzDepartment of Rheumatology and Clinical Immunology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg i.Br., Germany.
Roland SchroersDepartment of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
Universitätsklinikum Knappschaftskrankenhaus Bochum · DEUniversity of Freiburg · DEUniversity of Lübeck · DECeGaT (Germany) · DERuhr University Bochum · DESchwarzwald-Baar Klinikum · DEUniversity Medical Center Freiburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a disorder of uncontrolled immune activation with distinct clinical features including fever, cytopenia, splenomegaly, and sepsis-like symptoms. In a young adolescent patient a novel germline

Indexed as

Genetic Predisposition to DiseaseGenetic VariationBiomarkersDisease ManagementFemaleGATA2 Transcription FactorGenetic Association StudiesHematopoietic Stem Cell TransplantationHumansImmunophenotypingKiller Cells, NaturalLymphohistiocytosis, HemophagocyticMaleMycobacterium Infections, NontuberculousPositron Emission Tomography Computed TomographyTreatment OutcomeBiomarkersGATA2 protein, humanGATA2 Transcription Factorallogeneic hematopoietic stem cell transplantationCD107aGATA2hemophagocytic lymphohistiocytosisnon-tuberculous mycobacteriosis

Identifiers

PMID34040617
PMCPMC8143047
OpenAlexW3161771370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.