Evidence map›Paper›PMID 34040511›Full record

ArticleFrontiers in synaptic neuroscience2021

Impact of Perineuronal Nets on Electrophysiology of Parvalbumin Interneurons, Principal Neurons, and Brain Oscillations: A Review.

Jereme C Wingert, Barbara A Sorg

Abstract read
In one paragraph

Article in Frontiers in synaptic neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Article
  2. Article
  3. Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Ventral pallidal perineuronal nets regulate opioid relapse.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jereme C WingertProgram in Neuroscience, Robert S. Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, United States.
Barbara A SorgProgram in Neuroscience, Robert S. Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, United States.

Funding

Perineuronal nets and cocaine-associated memoriesR01DA040965 · NIDA · WASHINGTON STATE UNIVERSITY · PI BROWN, TRAVIS EUGENE, SORG, BARBARA A · 2016 to 2020
$2.0M
Identifying Prefrontal Cortex Neural Ensembles in Cocaine-associated MemoriesR21DA047121 · NIDA · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · PI SORG, BARBARA A · 2019 to 2020
$475k
NIDA NIH HHS R01 DA040965NIDA NIH HHS R21 DA047121
6 · The paper itself

Abstract

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround specific neurons in the brain and spinal cord, appear during critical periods of development, and restrict plasticity during adulthood. Removal of PNNs can reinstate juvenile-like plasticity or, in cases of PNN removal during early developmental stages, PNN removal extends the critical plasticity period. PNNs surround mainly parvalbumin (PV)-containing, fast-spiking GABAergic interneurons in several brain regions. These inhibitory interneurons profoundly inhibit the network of surrounding neurons

Indexed as

memoryoscillationsparvalbuminperineuronal nets (PNNs)plasticity

Identifiers

PMID34040511
PMCPMC8141737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.