ArticleClinical interventions in aging2021
Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis.
Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Inflammatory biomarkers in cerebral venous thrombosis versus ischemic stroke: a network meta-analysis.Frontiers in neurology · 2025Pooled it
- Prognostic assessment of acute ischemic stroke by systemic immune-inflammatory index: a comprehensive meta-analysis of multidimensional outcomes.Frontiers in neurology · 2025Pooled it
- Association of the systemic immune-inflammation index (SII) and clinical outcomes in patients with stroke: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Admission Systemic Immune-Inflammation Index Is Associated with Cognitive Performance and Handgrip Strength Three Months After First-Ever Acute Ischaemic Stroke: A Prospective Cohort Study.Brain sciences · 2026Article
- Identification of the Dynamic Expression Patterns of Immune Genes in the Peripheral Blood of Acute Ischemic Stroke Patients.Biochemical genetics · 2026Article
- Systemic Immune-Inflammatory Markers for Predicting Infarct Volume and Mortality in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Association and Comparative Analysis of Four Inflammatory Indices With 90-Day Outcomes in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis.Brain and behavior · 2026Article
- A multimarker panel for predicting short-term outcome after intravenous thrombolysis in acute ischemic stroke: a retrospective study.Frontiers in medicine · 2026Article
- Serial immune-inflammatory recovery trajectories after acute ischemic stroke: associations with early neurological deterioration and 90-day functional outcome in a retrospective cohort.Frontiers in neurology · 2026Article
- Association of the systemic immune-inflammation index with consciousness disturbance in cerebral venous sinus thrombosis: a retrospective cohort study.Frontiers in immunology · 2026Article
- Inflammatory Response Indices in Patients with Acute Ischemic Stroke Treated with and Without Reperfusion Therapy.Journal of clinical medicine · 2025Article
- Biomarkers and Mechanisms of Cardiovascular Susceptibility and Resilience to Post-Traumatic Stress Disorder.Reviews in cardiovascular medicine · 2025Review
- Predictive value of traditional laboratory parameters and inflammatory indices for same-day seizure recurrence in patients with epileptic seizures.Epilepsia open · 2025Article
- Superiority of pan-immune inflammation value, systemic inflammation index, and CALLY scores prognostic value for mortality of ischemic stroke patients followed in intensive care unit.BMC immunology · 2025Article
- Preoperative systemic immune-inflammation index as a superior predictor for postoperative outcomes in brain tumor patients undergoing craniotomy.Neurosurgical review · 2025Article
- Influencing factors and predictive models of early post-stroke depression in patients with acute ischemic stroke.BMC neurology · 2025Article
- Pan-Immune-Inflammation Value Predicts 3-Month Functional Outcomes in Patients With Acute Ischemic Stroke Treated With Mechanical Thrombectomy.Brain and behavior · 2025Article
- Systemic immune-inflammation index associated with functional outcomes after endovascular thrombectomy in anterior circulation acute ischemic stroke.Frontiers in neurology · 2025Article
- Systemic inflammation-based hematological indices and 90-day functional outcomes after intravenous thrombolysis in acute ischemic stroke: a systematic review.Frontiers in neurology · 2025Review
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSystemic immune-inflammation index (SII), a novel inflammation index derived from counts of circulating platelets, neutrophils and lymphocytes, has been studied in developing incident cancer. However, the clinical value of SII in acute ischemic stroke (AIS) patients had not been further investigated. Therefore, we aimed to explore the association between SII and severity of stroke as well as 3-month outcome of AIS patients.
methodsA total of 216 AIS patients receiving intravenous thrombolysis (IVT) and 875 healthy controls (HCs) were retrospectively recruited. Blood samples were collected within 24h after admission. Severity of stroke was assessed by the National Institute of Health stroke scale (NIHSS) scores on admission and poor 3-month functional outcome was defined as Modified Rankin Scale (mRS) > 2.
resultsSII levels in AIS patients were higher than in HCs. The cut-off value of SII is 545.14×10
conclusionSII is correlated with stroke severity at admission and can be a novel prognostic biomarker for AIS patients treated with IVT.
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