Evidence map›Paper›PMID 34040362›Full record

ArticleClinical interventions in aging2021

Eosinophil-to-Monocyte Ratio is a Potential Predictor of Prognosis in Acute Ischemic Stroke Patients After Intravenous Thrombolysis.

Yueping Chen, Junli Ren, Naiping Yang, Honghao Huang, Xueting Hu, Fangyue Sun, Tian Zeng, Xinbo Zhou, Wenjing Pan, Jingyu Hu and 3 more

Abstract read
In one paragraph

Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yueping Chen *Clinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Junli Ren *Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Naiping Yang *Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Honghao HuangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Xueting HuDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Fangyue SunDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Tian ZengDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Xinbo ZhouDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Wenjing PanDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Jingyu HuDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Beibei GaoDepartment of Internal Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Shunkai ZhangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Guangyong ChenDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.ORCID 0000-0003-1818-6280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEosinophil and monocyte have been demonstrated separately to be independent predictors of acute ischemic stroke (AIS). This study aimed to evaluate the association between eosinophil-to-monocyte ratio (EMR) and 3-month clinical outcome after treatment with recombinant tissue plasminogen activator (rt-PA) for AIS patients. Simultaneously, we made a simple comparison with other prognostic indicators, such as 24h neutrophil-to-lymphocyte ratio (NLR) and 24h platelet-to-lymphocyte ratio (PLR) to investigate the prognostic value of EMR. METHODS AND

resultsA total of 280 AIS patients receiving intravenous thrombolysis were retrospectively recruited for this study. Complete blood count evaluations for EMR were conducted on 24 hours admission. The poor outcome at 3-month was defined as the modified Rankin Scale (mRS) of 3-6 and the mRS score for death was 6. The EMR levels in patients with AIS were lower than those in the healthy controls and showed a negative correlation with the NIHSS score. At the 3-month follow-up, multivariate logistic regression analysis indicated an association among EMR, poor outcome and mortality. In addition, EMR had a higher predictive ability than popular biomarkers like NLR and PLR for 3-month mortality.

conclusionThe lower levels of EMR were independently associated with poor outcome and dead status in AIS patients.

Indexed as

Administration, IntravenousAgedBiomarkersEosinophilsFemaleFibrinolytic AgentsHumansIschemic StrokeLymphocytesMaleMiddle AgedMonocytesNeutrophilsPrognosisRetrospective StudiesThrombolytic TherapyBiomarkersFibrinolytic AgentsTissue Plasminogen Activatoracute ischemic strokeeosinophil-to-monocyte ratiointravenous thrombolysismodified rankin scaletreatment outcome

Identifiers

PMID34040362
PMCPMC8139679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.