Evidence map›Paper›PMID 34040257›Full record

ArticleNature2021

An invariant Trypanosoma vivax vaccine antigen induces protective immunity.

Delphine Autheman, Cécile Crosnier, Simon Clare, David A Goulding, Cordelia Brandt, Katherine Harcourt, Charlotte Tolley, Francis Galaway, Malhar Khushu, Han Ong and 4 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Pathogens (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies.International journal for parasitology. Drugs and drug resistance · 2024
    Review
  14. Article
  15. Review
  16. Review
  17. PolyaromaticMolecules (Basel, Switzerland) · 2023
    Article
  18. Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Delphine AuthemanCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Cécile CrosnierCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Simon ClarePathogen Support Team, Wellcome Sanger Institute, Hinxton, UK.
David A GouldingElectron and Advanced Light Microscopy, Wellcome Sanger Institute, Hinxton, UK.
Cordelia BrandtPathogen Support Team, Wellcome Sanger Institute, Hinxton, UK.
Katherine HarcourtPathogen Support Team, Wellcome Sanger Institute, Hinxton, UK.
Charlotte TolleyPathogen Support Team, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-1119-7983
Francis GalawayCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Malhar KhushuCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Han OngCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Alessandra Romero-RamirezDepartment of Infection Biology and Microbiomes, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-8610-7815
Craig W DuffyDepartment of Infection Biology and Microbiomes, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-9359-4888
Andrew P JacksonDepartment of Infection Biology and Microbiomes, University of Liverpool, Liverpool, UK.
Gavin J WrightCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK. gw2@sanger.ac.uk.ORCID http://orcid.org/0000-0003-0537-0863
Wellcome Sanger Institute · GBUniversity of Liverpool · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S001980/1Wellcome Trust 206194Wellcome Trust BB/S001980/1
6 · The paper itself

Abstract

Trypanosomes are protozoan parasites that cause infectious diseases, including African trypanosomiasis (sleeping sickness) in humans and nagana in economically important livestock

Indexed as

AnimalsAntigens, ProtozoanComplement System ProteinsConserved SequenceDisease Models, AnimalFemaleFlagellaMiceMice, Inbred BALB CProtozoan VaccinesTime FactorsTrypanosoma vivaxTrypanosomiasis, AfricanVaccines, SubunitAntigens, ProtozoanComplement System ProteinsProtozoan VaccinesVaccines, Subunit

Identifiers

PMID34040257
OpenAlexW3165493869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.