Evidence map›Paper›PMID 34040255›Full record

ArticleNature2021

A phase-separated nuclear GBPL circuit controls immunity in plants.

Shuai Huang, Shiwei Zhu, Pradeep Kumar, John D MacMicking

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 156 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026
    Review
  5. Review
  6. Review
  7. Article
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  11. Article
  12. Article
  13. Review
  14. Stripe rust fungus subverts wheat phase separation-mediated immunity to promote infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Shuai HuangHoward Hughes Medical Institute, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8903-122X
Shiwei ZhuHoward Hughes Medical Institute, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1145-1192
Pradeep KumarHoward Hughes Medical Institute, New Haven, CT, USA.
John D MacMickingHoward Hughes Medical Institute, New Haven, CT, USA. john.macmicking@yale.edu.ORCID http://orcid.org/0000-0002-1734-135X
Howard Hughes Medical Institute · US

Funding

Immune control of tuberculosis by IFN-gamma-inducible LRG-47R01AI068041 · NIAID · YALE UNIVERSITY · PI MACMICKING, JOHN DAVID · 2006 to 2021
$5.9M
GBPs in inflammasome activation and host defense to infectionR01AI108834 · NIAID · YALE UNIVERSITY · PI John David MacMicking · 2014 to 2026
$5.0M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI068041NIAID NIH HHS R01 AI108834NIH HHS R01 AI068041-12NIH HHS R01 AI108834-05
6 · The paper itself

Abstract

Liquid-liquid phase separation (LLPS) has emerged as a central paradigm for understanding how membraneless organelles compartmentalize diverse cellular activities in eukaryotes

Indexed as

Phase TransitionPlant ImmunityArabidopsisCell NucleusChromatinCryoelectron MicroscopyGene Expression Regulation, PlantGTP-Binding ProteinsIntrinsically Disordered ProteinsMediator ComplexMultigene FamilyOrganellesPlant CellsPlant DiseasesPromoter Regions, GeneticRNA Polymerase IIChromatinGTP-Binding ProteinsIntrinsically Disordered ProteinsMediator ComplexRNA Polymerase II

Identifiers

PMID34040255
PMCPMC8478157
OpenAlexW3165739961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.